Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease

Abstract Patients with Parkinson’s disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-related cognitive impairments during interval timing...

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Autores principales:	Arun Singh, Rachel C. Cole, Arturo I. Espinoza, Aron Evans, Scarlett Cao, James F. Cavanagh, Nandakumar S. Narayanan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8bed2399f3924f909f1dfe1750bc593f
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spelling	oai:doaj.org-article:8bed2399f3924f909f1dfe1750bc593f2021-12-02T10:54:07ZTiming variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease10.1038/s41531-021-00158-x2373-8057https://doaj.org/article/8bed2399f3924f909f1dfe1750bc593f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00158-xhttps://doaj.org/toc/2373-8057Abstract Patients with Parkinson’s disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-related cognitive impairments during interval timing, which requires participants to estimate temporal intervals of several seconds. Time estimation is an ideal task demand for investigating cognition in PD because it is simple, requires medial frontal cortical areas, and recruits basic executive processes such as working memory and attention. However, interval timing has never been systematically studied in PD patients with cognitive impairments. We report three main findings. First, 71 PD patients had increased temporal variability compared to 37 demographically matched controls, and this variability correlated with cognitive dysfunction as measured by the Montreal Cognitive Assessment (MOCA). Second, PD patients had attenuated ~4 Hz EEG oscillatory activity at midfrontal electrodes in response to the interval-onset cue, which was also predictive of MOCA. Finally, trial-by-trial linear mixed-effects modeling demonstrated that cue-triggered ~4 Hz power predicted subsequent temporal estimates as a function of PD and MOCA. Our data suggest that impaired cue-evoked midfrontal ~4 Hz activity predicts increased timing variability that is indicative of cognitive dysfunction in PD. These findings link PD-related cognitive dysfunction with cortical mechanisms of cognitive control, which could advance novel biomarkers and neuromodulation for PD.Arun SinghRachel C. ColeArturo I. EspinozaAron EvansScarlett CaoJames F. CavanaghNandakumar S. NarayananNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Arun Singh Rachel C. Cole Arturo I. Espinoza Aron Evans Scarlett Cao James F. Cavanagh Nandakumar S. Narayanan Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
description	Abstract Patients with Parkinson’s disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-related cognitive impairments during interval timing, which requires participants to estimate temporal intervals of several seconds. Time estimation is an ideal task demand for investigating cognition in PD because it is simple, requires medial frontal cortical areas, and recruits basic executive processes such as working memory and attention. However, interval timing has never been systematically studied in PD patients with cognitive impairments. We report three main findings. First, 71 PD patients had increased temporal variability compared to 37 demographically matched controls, and this variability correlated with cognitive dysfunction as measured by the Montreal Cognitive Assessment (MOCA). Second, PD patients had attenuated ~4 Hz EEG oscillatory activity at midfrontal electrodes in response to the interval-onset cue, which was also predictive of MOCA. Finally, trial-by-trial linear mixed-effects modeling demonstrated that cue-triggered ~4 Hz power predicted subsequent temporal estimates as a function of PD and MOCA. Our data suggest that impaired cue-evoked midfrontal ~4 Hz activity predicts increased timing variability that is indicative of cognitive dysfunction in PD. These findings link PD-related cognitive dysfunction with cortical mechanisms of cognitive control, which could advance novel biomarkers and neuromodulation for PD.
format	article
author	Arun Singh Rachel C. Cole Arturo I. Espinoza Aron Evans Scarlett Cao James F. Cavanagh Nandakumar S. Narayanan
author_facet	Arun Singh Rachel C. Cole Arturo I. Espinoza Aron Evans Scarlett Cao James F. Cavanagh Nandakumar S. Narayanan
author_sort	Arun Singh
title	Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
title_short	Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
title_full	Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
title_fullStr	Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
title_full_unstemmed	Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease
title_sort	timing variability and midfrontal ~4 hz rhythms correlate with cognition in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bed2399f3924f909f1dfe1750bc593f
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Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson’s disease

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