Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.

The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin a...

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Autores principales:	Sergio González, David Moreno-Delgado, Estefanía Moreno, Kamil Pérez-Capote, Rafael Franco, Josefa Mallol, Antoni Cortés, Vicent Casadó, Carme Lluís, Jordi Ortiz, Sergi Ferré, Enric Canela, Peter J McCormick
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8bed974b365c4c47beb867828b5fe724
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spelling	oai:doaj.org-article:8bed974b365c4c47beb867828b5fe7242021-11-18T05:36:37ZCircadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.1544-91731545-788510.1371/journal.pbio.1001347https://doaj.org/article/8bed974b365c4c47beb867828b5fe7242012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723743/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D₄ receptors. Through α(₁B)-D₄ and β₁-D₄ receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D₄ was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D₄ receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs.Sergio GonzálezDavid Moreno-DelgadoEstefanía MorenoKamil Pérez-CapoteRafael FrancoJosefa MallolAntoni CortésVicent CasadóCarme LluísJordi OrtizSergi FerréEnric CanelaPeter J McCormickPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 6, p e1001347 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sergio González David Moreno-Delgado Estefanía Moreno Kamil Pérez-Capote Rafael Franco Josefa Mallol Antoni Cortés Vicent Casadó Carme Lluís Jordi Ortiz Sergi Ferré Enric Canela Peter J McCormick Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
description	The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D₄ receptors. Through α(₁B)-D₄ and β₁-D₄ receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D₄ was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D₄ receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs.
format	article
author	Sergio González David Moreno-Delgado Estefanía Moreno Kamil Pérez-Capote Rafael Franco Josefa Mallol Antoni Cortés Vicent Casadó Carme Lluís Jordi Ortiz Sergi Ferré Enric Canela Peter J McCormick
author_facet	Sergio González David Moreno-Delgado Estefanía Moreno Kamil Pérez-Capote Rafael Franco Josefa Mallol Antoni Cortés Vicent Casadó Carme Lluís Jordi Ortiz Sergi Ferré Enric Canela Peter J McCormick
author_sort	Sergio González
title	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
title_short	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
title_full	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
title_fullStr	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
title_full_unstemmed	Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.
title_sort	circadian-related heteromerization of adrenergic and dopamine d₄ receptors modulates melatonin synthesis and release in the pineal gland.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8bed974b365c4c47beb867828b5fe724
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Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.

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