Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19

Abstract Adaptive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics remain largely unknown. The neutralizing antibody (NAb) levels in patients with coronavirus disease 2019 (COVID-19) are helpful for understanding the pathology. Using SARS-CoV-2 pseudotyped virus, ser...

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Autores principales:	Hitoshi Kawasuji, Yoshitomo Morinaga, Hideki Tani, Miyuki Kimura, Hiroshi Yamada, Yoshihiro Yoshida, Yusuke Takegoshi, Makito Kaneda, Yushi Murai, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Koyomi Kawago, Yasutaka Fukui, Ippei Sakamaki, Yoshihiro Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8beed82176484596aa1bd15d7e9025b1
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spelling	oai:doaj.org-article:8beed82176484596aa1bd15d7e9025b12021-12-02T17:08:44ZDelayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-1910.1038/s41598-021-96143-82045-2322https://doaj.org/article/8beed82176484596aa1bd15d7e9025b12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96143-8https://doaj.org/toc/2045-2322Abstract Adaptive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics remain largely unknown. The neutralizing antibody (NAb) levels in patients with coronavirus disease 2019 (COVID-19) are helpful for understanding the pathology. Using SARS-CoV-2 pseudotyped virus, serum sample neutralization values in symptomatic COVID-19 patients were measured using the chemiluminescence reduction neutralization test (CRNT). At least two sequential serum samples collected during hospitalization were analyzed to assess NAbs neutralizing activity dynamics at different time points. Of the 11 patients, four (36.4%), six (54.5%), and one (9.1%) had moderate, severe, and critical disease, respectively. Fifty percent neutralization (N50%-CRNT) was observed upon admission in 90.9% (10/11); all patients acquired neutralizing activity 2–12 days after onset. In patients with moderate disease, neutralization was observed at earliest within two days after symptom onset. In patients with severe-to-critical disease, neutralization activity increased, plateauing 9–16 days after onset. Neutralization activity on admission was significantly higher in patients with moderate disease than in patients with severe-to-critical disease (relative % of infectivity, 6.4% vs. 41.1%; P = .011). Neutralization activity on admission inversely correlated with disease severity. The rapid NAb response may play a crucial role in preventing the progression of COVID-19.Hitoshi KawasujiYoshitomo MorinagaHideki TaniMiyuki KimuraHiroshi YamadaYoshihiro YoshidaYusuke TakegoshiMakito KanedaYushi MuraiKou KimotoAkitoshi UenoYuki MiyajimaKoyomi KawagoYasutaka FukuiIppei SakamakiYoshihiro YamamotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hitoshi Kawasuji Yoshitomo Morinaga Hideki Tani Miyuki Kimura Hiroshi Yamada Yoshihiro Yoshida Yusuke Takegoshi Makito Kaneda Yushi Murai Kou Kimoto Akitoshi Ueno Yuki Miyajima Koyomi Kawago Yasutaka Fukui Ippei Sakamaki Yoshihiro Yamamoto Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
description	Abstract Adaptive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics remain largely unknown. The neutralizing antibody (NAb) levels in patients with coronavirus disease 2019 (COVID-19) are helpful for understanding the pathology. Using SARS-CoV-2 pseudotyped virus, serum sample neutralization values in symptomatic COVID-19 patients were measured using the chemiluminescence reduction neutralization test (CRNT). At least two sequential serum samples collected during hospitalization were analyzed to assess NAbs neutralizing activity dynamics at different time points. Of the 11 patients, four (36.4%), six (54.5%), and one (9.1%) had moderate, severe, and critical disease, respectively. Fifty percent neutralization (N50%-CRNT) was observed upon admission in 90.9% (10/11); all patients acquired neutralizing activity 2–12 days after onset. In patients with moderate disease, neutralization was observed at earliest within two days after symptom onset. In patients with severe-to-critical disease, neutralization activity increased, plateauing 9–16 days after onset. Neutralization activity on admission was significantly higher in patients with moderate disease than in patients with severe-to-critical disease (relative % of infectivity, 6.4% vs. 41.1%; P = .011). Neutralization activity on admission inversely correlated with disease severity. The rapid NAb response may play a crucial role in preventing the progression of COVID-19.
format	article
author	Hitoshi Kawasuji Yoshitomo Morinaga Hideki Tani Miyuki Kimura Hiroshi Yamada Yoshihiro Yoshida Yusuke Takegoshi Makito Kaneda Yushi Murai Kou Kimoto Akitoshi Ueno Yuki Miyajima Koyomi Kawago Yasutaka Fukui Ippei Sakamaki Yoshihiro Yamamoto
author_facet	Hitoshi Kawasuji Yoshitomo Morinaga Hideki Tani Miyuki Kimura Hiroshi Yamada Yoshihiro Yoshida Yusuke Takegoshi Makito Kaneda Yushi Murai Kou Kimoto Akitoshi Ueno Yuki Miyajima Koyomi Kawago Yasutaka Fukui Ippei Sakamaki Yoshihiro Yamamoto
author_sort	Hitoshi Kawasuji
title	Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
title_short	Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
title_full	Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
title_fullStr	Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
title_full_unstemmed	Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19
title_sort	delayed neutralizing antibody response in the acute phase correlates with severe progression of covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8beed82176484596aa1bd15d7e9025b1
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Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19

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