LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that LTβR deficiency promotes survival in a mouse leuka...

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Autores principales:	S. S. Höpner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bf20fdc21164bb0a145089a5033e21d
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spelling	oai:doaj.org-article:8bf20fdc21164bb0a145089a5033e21d2021-12-02T10:54:04ZLIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells10.1038/s41467-021-21317-x2041-1723https://doaj.org/article/8bf20fdc21164bb0a145089a5033e21d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21317-xhttps://doaj.org/toc/2041-1723Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that LTβR deficiency promotes survival in a mouse leukaemia model.S. S. HöpnerAna RaykovaR. RadpourM. A. AmreinD. KollerG. M. BaerlocherC. RietherA. F. OchsenbeinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. S. Höpner Ana Raykova R. Radpour M. A. Amrein D. Koller G. M. Baerlocher C. Riether A. F. Ochsenbein LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
description	Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that LTβR deficiency promotes survival in a mouse leukaemia model.
format	article
author	S. S. Höpner Ana Raykova R. Radpour M. A. Amrein D. Koller G. M. Baerlocher C. Riether A. F. Ochsenbein
author_facet	S. S. Höpner Ana Raykova R. Radpour M. A. Amrein D. Koller G. M. Baerlocher C. Riether A. F. Ochsenbein
author_sort	S. S. Höpner
title	LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
title_short	LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
title_full	LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
title_fullStr	LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
title_full_unstemmed	LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
title_sort	light/ltβr signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bf20fdc21164bb0a145089a5033e21d
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LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

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