Apelin and Vasopressin: The Yin and Yang of Water Balance

Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in rodents have shown that apelin has an aquaretic effect via its central and renal actions. In the brain, apelin inhibits the phasic electrical...

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Autores principales:	Pierre-Emmanuel Girault-Sotias, Romain Gerbier, Adrien Flahault, Nadia de Mota, Catherine Llorens-Cortes
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	apelin vasopressin apelin receptor metabolically stable apelin-17 analogs diuresis osmolality Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/8bf2bd456ac14242904795752046d997
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spelling	oai:doaj.org-article:8bf2bd456ac14242904795752046d9972021-11-22T06:30:25ZApelin and Vasopressin: The Yin and Yang of Water Balance1664-239210.3389/fendo.2021.735515https://doaj.org/article/8bf2bd456ac14242904795752046d9972021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.735515/fullhttps://doaj.org/toc/1664-2392Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in rodents have shown that apelin has an aquaretic effect via its central and renal actions. In the brain, apelin inhibits the phasic electrical activity of vasopressinergic neurons and the release of vasopressin from the posterior pituitary into the bloodstream and in the kidney, apelin regulates renal microcirculation and counteracts in the collecting duct, the antidiuretic effect of vasopressin occurring via the vasopressin receptor type 2. In humans and rodents, if plasma osmolality is increased by hypertonic saline infusion/water deprivation or decreased by water loading, plasma vasopressin and apelin are conversely regulated to maintain body fluid homeostasis. In patients with the syndrome of inappropriate antidiuresis, in which vasopressin hypersecretion leads to hyponatremia, the balance between apelin and vasopressin is significantly altered. In order to re-establish the correct balance, a metabolically stable apelin-17 analog, LIT01-196, was developed, to overcome the problem of the very short half-life (in the minute range) of apelin in vivo. In a rat experimental model of vasopressin-induced hyponatremia, subcutaneously (s.c.) administered LIT01-196 blocks the antidiuretic effect of vasopressin and the vasopressin-induced increase in urinary osmolality, and induces a progressive improvement in hyponatremia, suggesting that apelin receptor activation constitutes an original approach for hyponatremia treatment.Pierre-Emmanuel Girault-SotiasRomain GerbierAdrien FlahaultNadia de MotaCatherine Llorens-CortesFrontiers Media S.A.articleapelinvasopressinapelin receptormetabolically stable apelin-17 analogsdiuresisosmolalityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apelin vasopressin apelin receptor metabolically stable apelin-17 analogs diuresis osmolality Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	apelin vasopressin apelin receptor metabolically stable apelin-17 analogs diuresis osmolality Diseases of the endocrine glands. Clinical endocrinology RC648-665 Pierre-Emmanuel Girault-Sotias Romain Gerbier Adrien Flahault Nadia de Mota Catherine Llorens-Cortes Apelin and Vasopressin: The Yin and Yang of Water Balance
description	Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in rodents have shown that apelin has an aquaretic effect via its central and renal actions. In the brain, apelin inhibits the phasic electrical activity of vasopressinergic neurons and the release of vasopressin from the posterior pituitary into the bloodstream and in the kidney, apelin regulates renal microcirculation and counteracts in the collecting duct, the antidiuretic effect of vasopressin occurring via the vasopressin receptor type 2. In humans and rodents, if plasma osmolality is increased by hypertonic saline infusion/water deprivation or decreased by water loading, plasma vasopressin and apelin are conversely regulated to maintain body fluid homeostasis. In patients with the syndrome of inappropriate antidiuresis, in which vasopressin hypersecretion leads to hyponatremia, the balance between apelin and vasopressin is significantly altered. In order to re-establish the correct balance, a metabolically stable apelin-17 analog, LIT01-196, was developed, to overcome the problem of the very short half-life (in the minute range) of apelin in vivo. In a rat experimental model of vasopressin-induced hyponatremia, subcutaneously (s.c.) administered LIT01-196 blocks the antidiuretic effect of vasopressin and the vasopressin-induced increase in urinary osmolality, and induces a progressive improvement in hyponatremia, suggesting that apelin receptor activation constitutes an original approach for hyponatremia treatment.
format	article
author	Pierre-Emmanuel Girault-Sotias Romain Gerbier Adrien Flahault Nadia de Mota Catherine Llorens-Cortes
author_facet	Pierre-Emmanuel Girault-Sotias Romain Gerbier Adrien Flahault Nadia de Mota Catherine Llorens-Cortes
author_sort	Pierre-Emmanuel Girault-Sotias
title	Apelin and Vasopressin: The Yin and Yang of Water Balance
title_short	Apelin and Vasopressin: The Yin and Yang of Water Balance
title_full	Apelin and Vasopressin: The Yin and Yang of Water Balance
title_fullStr	Apelin and Vasopressin: The Yin and Yang of Water Balance
title_full_unstemmed	Apelin and Vasopressin: The Yin and Yang of Water Balance
title_sort	apelin and vasopressin: the yin and yang of water balance
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8bf2bd456ac14242904795752046d997
work_keys_str_mv	AT pierreemmanuelgiraultsotias apelinandvasopressintheyinandyangofwaterbalance AT romaingerbier apelinandvasopressintheyinandyangofwaterbalance AT adrienflahault apelinandvasopressintheyinandyangofwaterbalance AT nadiademota apelinandvasopressintheyinandyangofwaterbalance AT catherinellorenscortes apelinandvasopressintheyinandyangofwaterbalance
_version_	1718418114741272576

Apelin and Vasopressin: The Yin and Yang of Water Balance

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