MicroRNA characteristics in epithelial ovarian cancer.

The purpose of the current study was to clarify differences in microRNA expression according to clinicopathological characteristics, and to investigate if miRNA profiles could predict cytoreductive outcome in patients with FIGO stage IIIC and IV ovarian cancer. Patients enrolled in the Pelvic Mass s...

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Autores principales:	Kira Philipsen Prahm, Claus Kim Høgdall, Mona Aarenstrup Karlsen, Ib Jarle Christensen, Guy Wayne Novotny, Estrid Høgdall
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bf50245e6ea4ad690a89d8b6c7a440d
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spelling	oai:doaj.org-article:8bf50245e6ea4ad690a89d8b6c7a440d2021-11-25T06:23:36ZMicroRNA characteristics in epithelial ovarian cancer.1932-620310.1371/journal.pone.0252401https://doaj.org/article/8bf50245e6ea4ad690a89d8b6c7a440d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252401https://doaj.org/toc/1932-6203The purpose of the current study was to clarify differences in microRNA expression according to clinicopathological characteristics, and to investigate if miRNA profiles could predict cytoreductive outcome in patients with FIGO stage IIIC and IV ovarian cancer. Patients enrolled in the Pelvic Mass study between 2004 and 2010, diagnosed and surgically treated for epithelial ovarian cancer, were used for investigation. MicroRNA was profiled from tumour tissue with global microRNA microarray analysis. Differences in miRNA expression profiles were analysed according to histologic subtype, FIGO stage, tumour grade, type I or II tumours and result of primary cytoreductive surgery. One microRNA, miR-130a, which was found to be associated with serous histology and advanced FIGO stage, was also validated using data from external cohorts. Another seven microRNAs (miR-34a, miR-455-3p, miR-595, miR-1301, miR-146-5p, 193a-5p, miR-939) were found to be significantly associated with the clinicopathological characteristics (p ≤ 0.001), in our data, but mere not similarly significant when tested against external cohorts. Further validation in comparable cohorts, with microRNA profiled using newest and similar methods are warranted.Kira Philipsen PrahmClaus Kim HøgdallMona Aarenstrup KarlsenIb Jarle ChristensenGuy Wayne NovotnyEstrid HøgdallPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252401 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kira Philipsen Prahm Claus Kim Høgdall Mona Aarenstrup Karlsen Ib Jarle Christensen Guy Wayne Novotny Estrid Høgdall MicroRNA characteristics in epithelial ovarian cancer.
description	The purpose of the current study was to clarify differences in microRNA expression according to clinicopathological characteristics, and to investigate if miRNA profiles could predict cytoreductive outcome in patients with FIGO stage IIIC and IV ovarian cancer. Patients enrolled in the Pelvic Mass study between 2004 and 2010, diagnosed and surgically treated for epithelial ovarian cancer, were used for investigation. MicroRNA was profiled from tumour tissue with global microRNA microarray analysis. Differences in miRNA expression profiles were analysed according to histologic subtype, FIGO stage, tumour grade, type I or II tumours and result of primary cytoreductive surgery. One microRNA, miR-130a, which was found to be associated with serous histology and advanced FIGO stage, was also validated using data from external cohorts. Another seven microRNAs (miR-34a, miR-455-3p, miR-595, miR-1301, miR-146-5p, 193a-5p, miR-939) were found to be significantly associated with the clinicopathological characteristics (p ≤ 0.001), in our data, but mere not similarly significant when tested against external cohorts. Further validation in comparable cohorts, with microRNA profiled using newest and similar methods are warranted.
format	article
author	Kira Philipsen Prahm Claus Kim Høgdall Mona Aarenstrup Karlsen Ib Jarle Christensen Guy Wayne Novotny Estrid Høgdall
author_facet	Kira Philipsen Prahm Claus Kim Høgdall Mona Aarenstrup Karlsen Ib Jarle Christensen Guy Wayne Novotny Estrid Høgdall
author_sort	Kira Philipsen Prahm
title	MicroRNA characteristics in epithelial ovarian cancer.
title_short	MicroRNA characteristics in epithelial ovarian cancer.
title_full	MicroRNA characteristics in epithelial ovarian cancer.
title_fullStr	MicroRNA characteristics in epithelial ovarian cancer.
title_full_unstemmed	MicroRNA characteristics in epithelial ovarian cancer.
title_sort	microrna characteristics in epithelial ovarian cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8bf50245e6ea4ad690a89d8b6c7a440d
work_keys_str_mv	AT kiraphilipsenprahm micrornacharacteristicsinepithelialovariancancer AT clauskimhøgdall micrornacharacteristicsinepithelialovariancancer AT monaaarenstrupkarlsen micrornacharacteristicsinepithelialovariancancer AT ibjarlechristensen micrornacharacteristicsinepithelialovariancancer AT guywaynenovotny micrornacharacteristicsinepithelialovariancancer AT estridhøgdall micrornacharacteristicsinepithelialovariancancer
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MicroRNA characteristics in epithelial ovarian cancer.

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