Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases

Abstract Objective To assess the performance of a combination of three quantitative MRI markers (iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis between amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Methods In total, 33 ALS, 12...

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Autores principales:	Antonietta Canna, Francesca Trojsi, Federica Di Nardo, Giuseppina Caiazzo, Gioacchino Tedeschi, Mario Cirillo, Fabrizio Esposito
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8bf52f1e28ca4c1cafda87f3953e494d
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spelling	oai:doaj.org-article:8bf52f1e28ca4c1cafda87f3953e494d2021-11-19T13:55:31ZCombining structural and metabolic markers in a quantitative MRI study of motor neuron diseases2328-950310.1002/acn3.51418https://doaj.org/article/8bf52f1e28ca4c1cafda87f3953e494d2021-09-01T00:00:00Zhttps://doi.org/10.1002/acn3.51418https://doaj.org/toc/2328-9503Abstract Objective To assess the performance of a combination of three quantitative MRI markers (iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis between amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Methods In total, 33 ALS, 12 PLS, and 28 healthy control (HC) subjects underwent a 3T MRI study including single‐ and multi‐echo sequences for gray matter (GM) volumetry and quantitative susceptibility mapping (QSM) and a pseudo‐continuous arterial spin labeling (ASL) sequence for cerebral blood flow (CBF) measurement. Mean values of QSM, CBF, and GM volumes were extracted in the motor cortex, basal ganglia, thalamus, amygdala, and hippocampus. A generalized linear model was applied to the three measures to binary discriminate between groups. The diagnostic performances were evaluated via receiver operating characteristic analyses. Results A significant discrimination was obtained: between ALS and HCs in the left and right motor cortex, where QSM increases were respectively associated with disability scores and disease duration; between PLS and ALS in the left motor cortex, where PLS patients resulted significantly more atrophic; between ALS and HC in the right motor cortex, where GM volumes were associated with upper motor neuron scores. Significant discrimination between ALS and HC was achieved in subcortical structures only combining all three parameters. Interpretation While increased QSM values in the motor cortex of ALS patients is a consolidated finding, combining QSM, CBF, and GM volumetry shows higher diagnostic potential for differentiating ALS patients from HC subjects and, in the motor cortex, between ALS and PLS.Antonietta CannaFrancesca TrojsiFederica Di NardoGiuseppina CaiazzoGioacchino TedeschiMario CirilloFabrizio EspositoWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 9, Pp 1774-1785 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Antonietta Canna Francesca Trojsi Federica Di Nardo Giuseppina Caiazzo Gioacchino Tedeschi Mario Cirillo Fabrizio Esposito Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
description	Abstract Objective To assess the performance of a combination of three quantitative MRI markers (iron deposition, basal neuronal metabolism, and regional atrophy) for differential diagnosis between amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Methods In total, 33 ALS, 12 PLS, and 28 healthy control (HC) subjects underwent a 3T MRI study including single‐ and multi‐echo sequences for gray matter (GM) volumetry and quantitative susceptibility mapping (QSM) and a pseudo‐continuous arterial spin labeling (ASL) sequence for cerebral blood flow (CBF) measurement. Mean values of QSM, CBF, and GM volumes were extracted in the motor cortex, basal ganglia, thalamus, amygdala, and hippocampus. A generalized linear model was applied to the three measures to binary discriminate between groups. The diagnostic performances were evaluated via receiver operating characteristic analyses. Results A significant discrimination was obtained: between ALS and HCs in the left and right motor cortex, where QSM increases were respectively associated with disability scores and disease duration; between PLS and ALS in the left motor cortex, where PLS patients resulted significantly more atrophic; between ALS and HC in the right motor cortex, where GM volumes were associated with upper motor neuron scores. Significant discrimination between ALS and HC was achieved in subcortical structures only combining all three parameters. Interpretation While increased QSM values in the motor cortex of ALS patients is a consolidated finding, combining QSM, CBF, and GM volumetry shows higher diagnostic potential for differentiating ALS patients from HC subjects and, in the motor cortex, between ALS and PLS.
format	article
author	Antonietta Canna Francesca Trojsi Federica Di Nardo Giuseppina Caiazzo Gioacchino Tedeschi Mario Cirillo Fabrizio Esposito
author_facet	Antonietta Canna Francesca Trojsi Federica Di Nardo Giuseppina Caiazzo Gioacchino Tedeschi Mario Cirillo Fabrizio Esposito
author_sort	Antonietta Canna
title	Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
title_short	Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
title_full	Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
title_fullStr	Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
title_full_unstemmed	Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases
title_sort	combining structural and metabolic markers in a quantitative mri study of motor neuron diseases
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/8bf52f1e28ca4c1cafda87f3953e494d
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Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases

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