RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.

<h4>Background</h4>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccin...

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Autores principales:	Mairaj Ahmed Ansari, Swaleha Zubair, Anjum Mahmood, Pushpa Gupta, Aijaz A Khan, Umesh D Gupta, Ashish Arora, Mohammad Owais
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bf7456ea53b41b38ec7a99414e4e65c
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spelling	oai:doaj.org-article:8bf7456ea53b41b38ec7a99414e4e65c2021-11-18T06:48:12ZRD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.1932-620310.1371/journal.pone.0022889https://doaj.org/article/8bf7456ea53b41b38ec7a99414e4e65c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21853054/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.<h4>Methods</h4>The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.<h4>Results</h4>Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.<h4>Conclusion</h4>The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.Mairaj Ahmed AnsariSwaleha ZubairAnjum MahmoodPushpa GuptaAijaz A KhanUmesh D GuptaAshish AroraMohammad OwaisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e22889 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mairaj Ahmed Ansari Swaleha Zubair Anjum Mahmood Pushpa Gupta Aijaz A Khan Umesh D Gupta Ashish Arora Mohammad Owais RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
description	<h4>Background</h4>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.<h4>Methods</h4>The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.<h4>Results</h4>Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.<h4>Conclusion</h4>The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.
format	article
author	Mairaj Ahmed Ansari Swaleha Zubair Anjum Mahmood Pushpa Gupta Aijaz A Khan Umesh D Gupta Ashish Arora Mohammad Owais
author_facet	Mairaj Ahmed Ansari Swaleha Zubair Anjum Mahmood Pushpa Gupta Aijaz A Khan Umesh D Gupta Ashish Arora Mohammad Owais
author_sort	Mairaj Ahmed Ansari
title	RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
title_short	RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
title_full	RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
title_fullStr	RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
title_full_unstemmed	RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
title_sort	rd antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8bf7456ea53b41b38ec7a99414e4e65c
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RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis.

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