Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma

Background: Arrhythmias are common cardiovascular complications in multiple myeloma (MM) patients and are related to a poor prognosis.Objective: This study aimed to assess the burden of arrhythmias and their prognostic value in patients with MM.Methods: This was a retrospective study of patients wit...

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Autores principales:	Yongxin Li, Manyun Tang, Liang Zhong, Suhua Wei, Jingzhuo Song, Hui Liu, Chaofeng Sun, Jie Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	risk stratification arrhythmias multiple myeloma prognosis cardiovascular complication Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/8bfdc28509dd45a1ab5be72af360d08e
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spelling	oai:doaj.org-article:8bfdc28509dd45a1ab5be72af360d08e2021-11-15T13:20:52ZIncidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma2297-055X10.3389/fcvm.2021.753918https://doaj.org/article/8bfdc28509dd45a1ab5be72af360d08e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.753918/fullhttps://doaj.org/toc/2297-055XBackground: Arrhythmias are common cardiovascular complications in multiple myeloma (MM) patients and are related to a poor prognosis.Objective: This study aimed to assess the burden of arrhythmias and their prognostic value in patients with MM.Methods: This was a retrospective study of patients with MM between January 2015 and April 2020 at the First Affiliated Hospital of Xi'an Jiaotong University. The incidence of arrhythmia and associated risk factors were evaluated. The relationship between the type of arrhythmia and survival was analyzed.Results: A total of 319 patients with MM were identified, and 48.0% (153/319) had arrhythmias. The most common type of arrhythmia was sinus tachycardia (ST) (15.0%, 48/319), followed by sinus bradycardia (SB) (14.4%, 46/319), premature atrial contractions (PACs) (6.3%, 20/319), conduction disorders (CDs) (6.0%, 19/319), atrial fibrillation (AF) (6.0%, 19/319), premature ventricular contractions (PVCs) (4.4%, 14/319) and paroxysmal supraventricular tachycardia (PSVT) (0.6%, 2/319). The patients with arrhythmias had higher levels of log NT-proBNP and creatinine, greater bortezomib use, and a higher incidence of diabetes than those without arrhythmias (P < 0.05). The all-cause mortality rates of patients without arrhythmias and those with AF, ST, PACs, CDs, SB, and PVCs were 50.6% (84/166), 73.7% (14/19), 60.4% (29/48), 60.0% (12/20), 52.6% (10/19), 34.8% (16/46), and 28.6% (4/14), respectively. In a subgroup analysis of patients experiencing different types of arrhythmias, patients with SB had lower all-cause mortality than patients with AF (P < 0.01). Univariate and multivariate Cox analyses showed that there was a positive statistically significant association between SB and survival (HR: 0.592 [0.352–0.998], P = 0.049) in a subgroup analysis of different arrhythmias.Conclusions: Patients with MM had a heavy arrhythmia burden, and in this study, approximately half of MM patients had arrhythmias. MM patients with SB were associated with lower all-cause mortality than those with AF. SB might be an independent positive factor for prognosis.Yongxin LiManyun TangLiang ZhongSuhua WeiJingzhuo SongHui LiuChaofeng SunJie WangJie WangFrontiers Media S.A.articlerisk stratificationarrhythmiasmultiple myelomaprognosiscardiovascular complicationDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	risk stratification arrhythmias multiple myeloma prognosis cardiovascular complication Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	risk stratification arrhythmias multiple myeloma prognosis cardiovascular complication Diseases of the circulatory (Cardiovascular) system RC666-701 Yongxin Li Manyun Tang Liang Zhong Suhua Wei Jingzhuo Song Hui Liu Chaofeng Sun Jie Wang Jie Wang Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
description	Background: Arrhythmias are common cardiovascular complications in multiple myeloma (MM) patients and are related to a poor prognosis.Objective: This study aimed to assess the burden of arrhythmias and their prognostic value in patients with MM.Methods: This was a retrospective study of patients with MM between January 2015 and April 2020 at the First Affiliated Hospital of Xi'an Jiaotong University. The incidence of arrhythmia and associated risk factors were evaluated. The relationship between the type of arrhythmia and survival was analyzed.Results: A total of 319 patients with MM were identified, and 48.0% (153/319) had arrhythmias. The most common type of arrhythmia was sinus tachycardia (ST) (15.0%, 48/319), followed by sinus bradycardia (SB) (14.4%, 46/319), premature atrial contractions (PACs) (6.3%, 20/319), conduction disorders (CDs) (6.0%, 19/319), atrial fibrillation (AF) (6.0%, 19/319), premature ventricular contractions (PVCs) (4.4%, 14/319) and paroxysmal supraventricular tachycardia (PSVT) (0.6%, 2/319). The patients with arrhythmias had higher levels of log NT-proBNP and creatinine, greater bortezomib use, and a higher incidence of diabetes than those without arrhythmias (P < 0.05). The all-cause mortality rates of patients without arrhythmias and those with AF, ST, PACs, CDs, SB, and PVCs were 50.6% (84/166), 73.7% (14/19), 60.4% (29/48), 60.0% (12/20), 52.6% (10/19), 34.8% (16/46), and 28.6% (4/14), respectively. In a subgroup analysis of patients experiencing different types of arrhythmias, patients with SB had lower all-cause mortality than patients with AF (P < 0.01). Univariate and multivariate Cox analyses showed that there was a positive statistically significant association between SB and survival (HR: 0.592 [0.352–0.998], P = 0.049) in a subgroup analysis of different arrhythmias.Conclusions: Patients with MM had a heavy arrhythmia burden, and in this study, approximately half of MM patients had arrhythmias. MM patients with SB were associated with lower all-cause mortality than those with AF. SB might be an independent positive factor for prognosis.
format	article
author	Yongxin Li Manyun Tang Liang Zhong Suhua Wei Jingzhuo Song Hui Liu Chaofeng Sun Jie Wang Jie Wang
author_facet	Yongxin Li Manyun Tang Liang Zhong Suhua Wei Jingzhuo Song Hui Liu Chaofeng Sun Jie Wang Jie Wang
author_sort	Yongxin Li
title	Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
title_short	Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
title_full	Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
title_fullStr	Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
title_full_unstemmed	Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma
title_sort	incidence of arrhythmias and their prognostic value in patients with multiple myeloma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8bfdc28509dd45a1ab5be72af360d08e
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Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma

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