Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation

Abstract The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-b...

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Autores principales:	Claudio Tucci, Macarena Trujillo, Enrique Berjano, Marcello Iasiello, Assunta Andreozzi, Giuseppe Peter Vanoli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bffc9b4ebaa47cf948868996ef4fcb0
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spelling	oai:doaj.org-article:8bffc9b4ebaa47cf948868996ef4fcb02021-12-02T13:34:32ZPennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation10.1038/s41598-021-84546-62045-2322https://doaj.org/article/8bffc9b4ebaa47cf948868996ef4fcb02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84546-6https://doaj.org/toc/2045-2322Abstract The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based models, i.e. the Local Thermal Non-Equilibrium (LTNE) equations and Local Thermal Equilibrium (LTE) equation, both modified to take into account two-phase water vaporization (tissue and blood). Different blood volume fractions in liver were considered and the blood velocity was modeled to simulate a vascular network. Governing equations with the appropriate boundary conditions were solved with Comsol Multiphysics finite-element code. The results in terms of coagulation transverse diameters and temperature distributions at the end of the application showed significant differences, especially between Pennes and the modified LTNE and LTE models. The new modified porous media-based models covered the ranges found in the few in vivo experimental studies in the literature and they were closer to the published results with similar in vivo protocol. The outcomes highlight the importance of considering the three models in the future in order to improve thermal ablation protocols and devices and adapt the model to different organs and patient profiles.Claudio TucciMacarena TrujilloEnrique BerjanoMarcello IasielloAssunta AndreozziGiuseppe Peter VanoliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claudio Tucci Macarena Trujillo Enrique Berjano Marcello Iasiello Assunta Andreozzi Giuseppe Peter Vanoli Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
description	Abstract The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes’ equation and two porous media-based models, i.e. the Local Thermal Non-Equilibrium (LTNE) equations and Local Thermal Equilibrium (LTE) equation, both modified to take into account two-phase water vaporization (tissue and blood). Different blood volume fractions in liver were considered and the blood velocity was modeled to simulate a vascular network. Governing equations with the appropriate boundary conditions were solved with Comsol Multiphysics finite-element code. The results in terms of coagulation transverse diameters and temperature distributions at the end of the application showed significant differences, especially between Pennes and the modified LTNE and LTE models. The new modified porous media-based models covered the ranges found in the few in vivo experimental studies in the literature and they were closer to the published results with similar in vivo protocol. The outcomes highlight the importance of considering the three models in the future in order to improve thermal ablation protocols and devices and adapt the model to different organs and patient profiles.
format	article
author	Claudio Tucci Macarena Trujillo Enrique Berjano Marcello Iasiello Assunta Andreozzi Giuseppe Peter Vanoli
author_facet	Claudio Tucci Macarena Trujillo Enrique Berjano Marcello Iasiello Assunta Andreozzi Giuseppe Peter Vanoli
author_sort	Claudio Tucci
title	Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_short	Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_full	Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_fullStr	Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_full_unstemmed	Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
title_sort	pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bffc9b4ebaa47cf948868996ef4fcb0
work_keys_str_mv	AT claudiotucci pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation AT macarenatrujillo pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation AT enriqueberjano pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation AT marcelloiasiello pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation AT assuntaandreozzi pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation AT giuseppepetervanoli pennesbioheatequationvsporousmediaapproachincomputermodelingofradiofrequencytumorablation
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Pennes’ bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation

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