A synaptic mechanism for temporal filtering of visual signals.

The visual system transmits information about fast and slow changes in light intensity through separate neural pathways. We used in vivo imaging to investigate how bipolar cells transmit these signals to the inner retina. We found that the volume of the synaptic terminal is an intrinsic property tha...

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Autores principales:	Tom Baden, Anton Nikolaev, Federico Esposti, Elena Dreosti, Benjamin Odermatt, Leon Lagnado
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8c02d8dbbf7b4b4790b8a1de6c10473d
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id	oai:doaj.org-article:8c02d8dbbf7b4b4790b8a1de6c10473d
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spelling	oai:doaj.org-article:8c02d8dbbf7b4b4790b8a1de6c10473d2021-11-25T05:32:55ZA synaptic mechanism for temporal filtering of visual signals.1544-91731545-788510.1371/journal.pbio.1001972https://doaj.org/article/8c02d8dbbf7b4b4790b8a1de6c10473d2014-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.1001972https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The visual system transmits information about fast and slow changes in light intensity through separate neural pathways. We used in vivo imaging to investigate how bipolar cells transmit these signals to the inner retina. We found that the volume of the synaptic terminal is an intrinsic property that contributes to different temporal filters. Individual cells transmit through multiple terminals varying in size, but smaller terminals generate faster and larger calcium transients to trigger vesicle release with higher initial gain, followed by more profound adaptation. Smaller terminals transmitted higher stimulus frequencies more effectively. Modeling global calcium dynamics triggering vesicle release indicated that variations in the volume of presynaptic compartments contribute directly to all these differences in response dynamics. These results indicate how one neuron can transmit different temporal components in the visual signal through synaptic terminals of varying geometries with different adaptational properties.Tom BadenAnton NikolaevFederico EspostiElena DreostiBenjamin OdermattLeon LagnadoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 10, p e1001972 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tom Baden Anton Nikolaev Federico Esposti Elena Dreosti Benjamin Odermatt Leon Lagnado A synaptic mechanism for temporal filtering of visual signals.
description	The visual system transmits information about fast and slow changes in light intensity through separate neural pathways. We used in vivo imaging to investigate how bipolar cells transmit these signals to the inner retina. We found that the volume of the synaptic terminal is an intrinsic property that contributes to different temporal filters. Individual cells transmit through multiple terminals varying in size, but smaller terminals generate faster and larger calcium transients to trigger vesicle release with higher initial gain, followed by more profound adaptation. Smaller terminals transmitted higher stimulus frequencies more effectively. Modeling global calcium dynamics triggering vesicle release indicated that variations in the volume of presynaptic compartments contribute directly to all these differences in response dynamics. These results indicate how one neuron can transmit different temporal components in the visual signal through synaptic terminals of varying geometries with different adaptational properties.
format	article
author	Tom Baden Anton Nikolaev Federico Esposti Elena Dreosti Benjamin Odermatt Leon Lagnado
author_facet	Tom Baden Anton Nikolaev Federico Esposti Elena Dreosti Benjamin Odermatt Leon Lagnado
author_sort	Tom Baden
title	A synaptic mechanism for temporal filtering of visual signals.
title_short	A synaptic mechanism for temporal filtering of visual signals.
title_full	A synaptic mechanism for temporal filtering of visual signals.
title_fullStr	A synaptic mechanism for temporal filtering of visual signals.
title_full_unstemmed	A synaptic mechanism for temporal filtering of visual signals.
title_sort	synaptic mechanism for temporal filtering of visual signals.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8c02d8dbbf7b4b4790b8a1de6c10473d
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A synaptic mechanism for temporal filtering of visual signals.

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