A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

Jinjin Shi,1,2 Yu Su,1 Wei Liu,1 Junbiao Chang,2 Zhenzhong Zhang1,2 1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 2Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, People’s Republic of China Abstract: Recently, stimuli-responsi...

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Autores principales:	Shi J, Su Y, Liu W, Chang J, Zhang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Drug delivery Photo-responsive release Photodynamic-chemotherapy photocatalysis multidrug resistance Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c03452d3f994341a35c4566fc57cd27
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spelling	oai:doaj.org-article:8c03452d3f994341a35c4566fc57cd272021-12-02T07:13:41ZA nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance1178-2013https://doaj.org/article/8c03452d3f994341a35c4566fc57cd272017-11-01T00:00:00Zhttps://www.dovepress.com/a-nanoliposome-based-photoactivable-drug-delivery-system-for-enhanced--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jinjin Shi,1,2 Yu Su,1 Wei Liu,1 Junbiao Chang,2 Zhenzhong Zhang1,2 1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 2Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, People’s Republic of China Abstract: Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug resistance in synchrony with a photoinitiated and rapid release of antitumor drug. The PNLs consist of a nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether [HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX) encapsulated inside. PNLs have several distinctive capabilities: 1) carrying high loadings of DOX and HMME and releasing the payloads in a photo-cleavage manner with high spatial/temporal resolution at the site of actions via photocatalysis; 2) reducing drug efflux in MCF-7/multidrug resistance cells via decreasing the level of P-glycoprotein induced by photodynamic therapy (PDT); 3) accumulating in tumor site taking advantage of the enhanced permeability and retention effect; and 4) combining effective chemotherapy and PDT to exert much enhanced anticancer effect and achieving significant tumor regression in a drug-resistant tumor model with little side effects. Keywords: drug delivery, photo-responsive release, photodynamic-chemotherapy, photocatalysis, multidrug resistanceShi JSu YLiu WChang JZhang ZDove Medical PressarticleDrug deliveryPhoto-responsive releasePhotodynamic-chemotherapyphotocatalysismultidrug resistanceMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8257-8275 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug delivery Photo-responsive release Photodynamic-chemotherapy photocatalysis multidrug resistance Medicine (General) R5-920
spellingShingle	Drug delivery Photo-responsive release Photodynamic-chemotherapy photocatalysis multidrug resistance Medicine (General) R5-920 Shi J Su Y Liu W Chang J Zhang Z A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
description	Jinjin Shi,1,2 Yu Su,1 Wei Liu,1 Junbiao Chang,2 Zhenzhong Zhang1,2 1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 2Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, People’s Republic of China Abstract: Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug resistance in synchrony with a photoinitiated and rapid release of antitumor drug. The PNLs consist of a nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether [HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX) encapsulated inside. PNLs have several distinctive capabilities: 1) carrying high loadings of DOX and HMME and releasing the payloads in a photo-cleavage manner with high spatial/temporal resolution at the site of actions via photocatalysis; 2) reducing drug efflux in MCF-7/multidrug resistance cells via decreasing the level of P-glycoprotein induced by photodynamic therapy (PDT); 3) accumulating in tumor site taking advantage of the enhanced permeability and retention effect; and 4) combining effective chemotherapy and PDT to exert much enhanced anticancer effect and achieving significant tumor regression in a drug-resistant tumor model with little side effects. Keywords: drug delivery, photo-responsive release, photodynamic-chemotherapy, photocatalysis, multidrug resistance
format	article
author	Shi J Su Y Liu W Chang J Zhang Z
author_facet	Shi J Su Y Liu W Chang J Zhang Z
author_sort	Shi J
title	A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
title_short	A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
title_full	A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
title_fullStr	A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
title_full_unstemmed	A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
title_sort	nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8c03452d3f994341a35c4566fc57cd27
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_version_	1718399587242213376

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

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