Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers

Hongli Yan,1,2,* Zhifeng Xue,1,2,* Jiarong Xie,1,2 Yixiao Dong,1,2 Zhe Ma,1,2 Xinru Sun,1,2 Dereje Kebebe Borga,1–3 Zhidong Liu,1,2 Jiawei Li2,4 1Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditi...

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Autores principales:	Yan H, Xue Z, Xie J, Dong Y, Ma Z, Sun X, Kebebe Borga D, Liu Z, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	anti-tumor cancer cnts nanometer preparation nanometer carrier toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c041dc2f51b49feabc571a7939e6eb6
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spelling	oai:doaj.org-article:8c041dc2f51b49feabc571a7939e6eb62021-12-02T09:15:32ZToxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers1178-2013https://doaj.org/article/8c041dc2f51b49feabc571a7939e6eb62019-12-01T00:00:00Zhttps://www.dovepress.com/toxicity-of-carbon-nanotubes-as-anti-tumor-drug-carriers-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hongli Yan,1,2,* Zhifeng Xue,1,2,* Jiarong Xie,1,2 Yixiao Dong,1,2 Zhe Ma,1,2 Xinru Sun,1,2 Dereje Kebebe Borga,1–3 Zhidong Liu,1,2 Jiawei Li2,4 1Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China; 2Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China; 3School of Pharmacy, Institute of Health Sciences, Jimma University, Jimma, Ethiopia; 4Institute of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhidong LiuTianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Jinghai, Tianjin 301617, People’s Republic of ChinaTel +86 22 5959 6163Email lonerliuzd@163.comJiawei LiInstitute of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Jinghai, Tianjin 301617, People’s Republic of ChinaTel +86 22 5959 6352Email lijiawei1981@163.comAbstract: Nanoparticle drug formulations have enormous application prospects owing to achievement of targeted and sustained release drug delivery, improvement in drug solubility and reduction of adverse drug reactions. Recently, a variety of efficient drug nanometer carriers have been developed, among which carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. However, these nanotubes exert various toxic effects on the body due to their unique physical and chemical properties. CNT-induced toxicity is related to surface modification, degree of aggregation in vivo, and nanoparticle concentration. This review has focused on the potential toxic effects of CNTs utilized as anti-tumor drug carriers. The main modes by which CNTs enter target sites, the toxicity expressive types and the factors affecting toxicity are discussed.Keywords: anti-tumor, cancer, CNTs, nanometer preparation, nanometer carrier, toxicityYan HXue ZXie JDong YMa ZSun XKebebe Borga DLiu ZLi JDove Medical Pressarticleanti-tumorcancercntsnanometer preparationnanometer carriertoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 10179-10194 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-tumor cancer cnts nanometer preparation nanometer carrier toxicity Medicine (General) R5-920
spellingShingle	anti-tumor cancer cnts nanometer preparation nanometer carrier toxicity Medicine (General) R5-920 Yan H Xue Z Xie J Dong Y Ma Z Sun X Kebebe Borga D Liu Z Li J Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
description	Hongli Yan,1,2,* Zhifeng Xue,1,2,* Jiarong Xie,1,2 Yixiao Dong,1,2 Zhe Ma,1,2 Xinru Sun,1,2 Dereje Kebebe Borga,1–3 Zhidong Liu,1,2 Jiawei Li2,4 1Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China; 2Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China; 3School of Pharmacy, Institute of Health Sciences, Jimma University, Jimma, Ethiopia; 4Institute of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhidong LiuTianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Jinghai, Tianjin 301617, People’s Republic of ChinaTel +86 22 5959 6163Email lonerliuzd@163.comJiawei LiInstitute of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Jinghai, Tianjin 301617, People’s Republic of ChinaTel +86 22 5959 6352Email lijiawei1981@163.comAbstract: Nanoparticle drug formulations have enormous application prospects owing to achievement of targeted and sustained release drug delivery, improvement in drug solubility and reduction of adverse drug reactions. Recently, a variety of efficient drug nanometer carriers have been developed, among which carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. However, these nanotubes exert various toxic effects on the body due to their unique physical and chemical properties. CNT-induced toxicity is related to surface modification, degree of aggregation in vivo, and nanoparticle concentration. This review has focused on the potential toxic effects of CNTs utilized as anti-tumor drug carriers. The main modes by which CNTs enter target sites, the toxicity expressive types and the factors affecting toxicity are discussed.Keywords: anti-tumor, cancer, CNTs, nanometer preparation, nanometer carrier, toxicity
format	article
author	Yan H Xue Z Xie J Dong Y Ma Z Sun X Kebebe Borga D Liu Z Li J
author_facet	Yan H Xue Z Xie J Dong Y Ma Z Sun X Kebebe Borga D Liu Z Li J
author_sort	Yan H
title	Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
title_short	Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
title_full	Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
title_fullStr	Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
title_full_unstemmed	Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
title_sort	toxicity of carbon nanotubes as anti-tumor drug carriers
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8c041dc2f51b49feabc571a7939e6eb6
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Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers

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