Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and vi...

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Autores principales: Lingyan Jiang, Peisheng Wang, Xiaorui Song, Huan Zhang, Shuangshuang Ma, Jingting Wang, Wanwu Li, Runxia Lv, Xiaoqian Liu, Shuai Ma, Jiaqi Yan, Haiyan Zhou, Di Huang, Zhihui Cheng, Chen Yang, Lu Feng, Lei Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/8c110fad8e2343f2846c5caea046f6e1
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spelling oai:doaj.org-article:8c110fad8e2343f2846c5caea046f6e12021-12-02T13:30:07ZSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence10.1038/s41467-021-21186-42041-1723https://doaj.org/article/8c110fad8e2343f2846c5caea046f6e12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21186-4https://doaj.org/toc/2041-1723Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.Lingyan JiangPeisheng WangXiaorui SongHuan ZhangShuangshuang MaJingting WangWanwu LiRunxia LvXiaoqian LiuShuai MaJiaqi YanHaiyan ZhouDi HuangZhihui ChengChen YangLu FengLei WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lingyan Jiang
Peisheng Wang
Xiaorui Song
Huan Zhang
Shuangshuang Ma
Jingting Wang
Wanwu Li
Runxia Lv
Xiaoqian Liu
Shuai Ma
Jiaqi Yan
Haiyan Zhou
Di Huang
Zhihui Cheng
Chen Yang
Lu Feng
Lei Wang
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
description Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.
format article
author Lingyan Jiang
Peisheng Wang
Xiaorui Song
Huan Zhang
Shuangshuang Ma
Jingting Wang
Wanwu Li
Runxia Lv
Xiaoqian Liu
Shuai Ma
Jiaqi Yan
Haiyan Zhou
Di Huang
Zhihui Cheng
Chen Yang
Lu Feng
Lei Wang
author_facet Lingyan Jiang
Peisheng Wang
Xiaorui Song
Huan Zhang
Shuangshuang Ma
Jingting Wang
Wanwu Li
Runxia Lv
Xiaoqian Liu
Shuai Ma
Jiaqi Yan
Haiyan Zhou
Di Huang
Zhihui Cheng
Chen Yang
Lu Feng
Lei Wang
author_sort Lingyan Jiang
title Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
title_short Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
title_full Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
title_fullStr Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
title_full_unstemmed Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
title_sort salmonella typhimurium reprograms macrophage metabolism via t3ss effector sope2 to promote intracellular replication and virulence
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8c110fad8e2343f2846c5caea046f6e1
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