Brown adipose tissue in the buccal fat pad during infancy.

<h4>Background</h4>The buccal fat pad (BFP) is an encapsulated mass of adipose tissue thought to enhance the sucking capabilities of the masticatory muscles during infancy. To date, no conclusive evidence has been provided as to the composition of the BFP in early postnatal life.<h4&g...

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Autores principales:	Skorn Ponrartana, Shilpa Patil, Patricia C Aggabao, Zdena Pavlova, Sherin U Devaskar, Vicente Gilsanz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c11124d18514df4a3becbef28f1c579
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spelling	oai:doaj.org-article:8c11124d18514df4a3becbef28f1c5792021-11-18T08:31:28ZBrown adipose tissue in the buccal fat pad during infancy.1932-620310.1371/journal.pone.0089533https://doaj.org/article/8c11124d18514df4a3becbef28f1c5792014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586852/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The buccal fat pad (BFP) is an encapsulated mass of adipose tissue thought to enhance the sucking capabilities of the masticatory muscles during infancy. To date, no conclusive evidence has been provided as to the composition of the BFP in early postnatal life.<h4>Objective</h4>The purpose of this study was to examine whether the BFP of neonates and infants is primarily composed of white adipose tissue (WAT) or brown adipose tissue (BAT).<h4>Materials and methods</h4>The percentage of fat in the BFP in 32 full-term infants (16 boys and 16 girls), aged one day to 10.6 months, was measured using magnetic resonance imaging (MRI) determinations of fat fraction.<h4>Results</h4>BFP fat fraction increased with age (r = 0.67; P<.0001) and neonates had significantly lower values when compared to older infants; 72.6 ± 9.6 vs. 91.8 ± 2.4, P<.0001. Multiple regression analysis indicated that the age-dependent relationship persisted after accounting for gender, gestational age, and weight percentile (P = .001). Two subjects (aged one and six days) depicted a change in the MRI characteristics of the BFP from primarily BAT to WAT at follow-up examinations two to six weeks later, respectively. Histological post-mortem studies of a 3 day and 1.1 month old revealed predominantly BAT and WAT in the BFP, respectively.<h4>Conclusion</h4>The BFP is primarily composed of BAT during the first weeks of life, but of WAT thereafter. Studies are needed to investigate the contributions of BAT in the BFP to infant feeding and how it is altered by postnatal nutrition.Skorn PonrartanaShilpa PatilPatricia C AggabaoZdena PavlovaSherin U DevaskarVicente GilsanzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89533 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Skorn Ponrartana Shilpa Patil Patricia C Aggabao Zdena Pavlova Sherin U Devaskar Vicente Gilsanz Brown adipose tissue in the buccal fat pad during infancy.
description	<h4>Background</h4>The buccal fat pad (BFP) is an encapsulated mass of adipose tissue thought to enhance the sucking capabilities of the masticatory muscles during infancy. To date, no conclusive evidence has been provided as to the composition of the BFP in early postnatal life.<h4>Objective</h4>The purpose of this study was to examine whether the BFP of neonates and infants is primarily composed of white adipose tissue (WAT) or brown adipose tissue (BAT).<h4>Materials and methods</h4>The percentage of fat in the BFP in 32 full-term infants (16 boys and 16 girls), aged one day to 10.6 months, was measured using magnetic resonance imaging (MRI) determinations of fat fraction.<h4>Results</h4>BFP fat fraction increased with age (r = 0.67; P<.0001) and neonates had significantly lower values when compared to older infants; 72.6 ± 9.6 vs. 91.8 ± 2.4, P<.0001. Multiple regression analysis indicated that the age-dependent relationship persisted after accounting for gender, gestational age, and weight percentile (P = .001). Two subjects (aged one and six days) depicted a change in the MRI characteristics of the BFP from primarily BAT to WAT at follow-up examinations two to six weeks later, respectively. Histological post-mortem studies of a 3 day and 1.1 month old revealed predominantly BAT and WAT in the BFP, respectively.<h4>Conclusion</h4>The BFP is primarily composed of BAT during the first weeks of life, but of WAT thereafter. Studies are needed to investigate the contributions of BAT in the BFP to infant feeding and how it is altered by postnatal nutrition.
format	article
author	Skorn Ponrartana Shilpa Patil Patricia C Aggabao Zdena Pavlova Sherin U Devaskar Vicente Gilsanz
author_facet	Skorn Ponrartana Shilpa Patil Patricia C Aggabao Zdena Pavlova Sherin U Devaskar Vicente Gilsanz
author_sort	Skorn Ponrartana
title	Brown adipose tissue in the buccal fat pad during infancy.
title_short	Brown adipose tissue in the buccal fat pad during infancy.
title_full	Brown adipose tissue in the buccal fat pad during infancy.
title_fullStr	Brown adipose tissue in the buccal fat pad during infancy.
title_full_unstemmed	Brown adipose tissue in the buccal fat pad during infancy.
title_sort	brown adipose tissue in the buccal fat pad during infancy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8c11124d18514df4a3becbef28f1c579
work_keys_str_mv	AT skornponrartana brownadiposetissueinthebuccalfatpadduringinfancy AT shilpapatil brownadiposetissueinthebuccalfatpadduringinfancy AT patriciacaggabao brownadiposetissueinthebuccalfatpadduringinfancy AT zdenapavlova brownadiposetissueinthebuccalfatpadduringinfancy AT sherinudevaskar brownadiposetissueinthebuccalfatpadduringinfancy AT vicentegilsanz brownadiposetissueinthebuccalfatpadduringinfancy
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Brown adipose tissue in the buccal fat pad during infancy.

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