A systematic review of potential screening biomarkers for active TB disease

Introduction: The standard TB Four Symptom Screen does not meet the World Health Organization (WHO) ideal screening criteria for having greater than 90% sensitivity to identify active TB disease, regardless of HIV status. To identify novel screening biomarkers for active TB, we performed a systemati...

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Autores principales:	James H. Wykowski, Chris Phillips, Thao Ngo, Paul K. Drain
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Tuberculosis Screening Systematic review Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8c11e9ebacf9483984d791d6efaa2811
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spelling	oai:doaj.org-article:8c11e9ebacf9483984d791d6efaa28112021-11-10T04:29:22ZA systematic review of potential screening biomarkers for active TB disease2405-579410.1016/j.jctube.2021.100284https://doaj.org/article/8c11e9ebacf9483984d791d6efaa28112021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405579421000735https://doaj.org/toc/2405-5794Introduction: The standard TB Four Symptom Screen does not meet the World Health Organization (WHO) ideal screening criteria for having greater than 90% sensitivity to identify active TB disease, regardless of HIV status. To identify novel screening biomarkers for active TB, we performed a systematic review of any cohort or case-control study reporting associations between screening biomarkers and active TB disease. Methods: We searched PubMed and Embase for articles published before October 10, 2021. We included studies from high or medium tuberculosis burden countries. We excluded articles focusing on C-reactive protein and lipoarabinomannan. For all included biomarkers, we calculated sensitivity, specificity and 95% confidence intervals, and assessed study quality using a tool adapted from the QUADAS-2 risk of bias. Results: From 8,062 abstracts screened, we included 79 articles. The articles described 302 unique biomarkers, including host antibodies, host proteins, TB antigens, microRNAs, whole blood gene PCRs, and combinations of biomarkers. Of these, 23 biomarkers had sensitivity greater than 90% and specificity greater than 70%, meeting WHO criteria for an ideal screening test. Among the eleven biomarkers described in people living with HIV, only one had a sensitivity greater than 90% and specificity greater than 70% for active TB. Conclusion: Further evaluation of biomarkers of active TB should be pursued to accelerate identification of TB disease.James H. WykowskiChris PhillipsThao NgoPaul K. DrainElsevierarticleTuberculosisScreeningSystematic reviewDiseases of the respiratory systemRC705-779Infectious and parasitic diseasesRC109-216ENJournal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 25, Iss , Pp 100284- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tuberculosis Screening Systematic review Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
spellingShingle	Tuberculosis Screening Systematic review Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216 James H. Wykowski Chris Phillips Thao Ngo Paul K. Drain A systematic review of potential screening biomarkers for active TB disease
description	Introduction: The standard TB Four Symptom Screen does not meet the World Health Organization (WHO) ideal screening criteria for having greater than 90% sensitivity to identify active TB disease, regardless of HIV status. To identify novel screening biomarkers for active TB, we performed a systematic review of any cohort or case-control study reporting associations between screening biomarkers and active TB disease. Methods: We searched PubMed and Embase for articles published before October 10, 2021. We included studies from high or medium tuberculosis burden countries. We excluded articles focusing on C-reactive protein and lipoarabinomannan. For all included biomarkers, we calculated sensitivity, specificity and 95% confidence intervals, and assessed study quality using a tool adapted from the QUADAS-2 risk of bias. Results: From 8,062 abstracts screened, we included 79 articles. The articles described 302 unique biomarkers, including host antibodies, host proteins, TB antigens, microRNAs, whole blood gene PCRs, and combinations of biomarkers. Of these, 23 biomarkers had sensitivity greater than 90% and specificity greater than 70%, meeting WHO criteria for an ideal screening test. Among the eleven biomarkers described in people living with HIV, only one had a sensitivity greater than 90% and specificity greater than 70% for active TB. Conclusion: Further evaluation of biomarkers of active TB should be pursued to accelerate identification of TB disease.
format	article
author	James H. Wykowski Chris Phillips Thao Ngo Paul K. Drain
author_facet	James H. Wykowski Chris Phillips Thao Ngo Paul K. Drain
author_sort	James H. Wykowski
title	A systematic review of potential screening biomarkers for active TB disease
title_short	A systematic review of potential screening biomarkers for active TB disease
title_full	A systematic review of potential screening biomarkers for active TB disease
title_fullStr	A systematic review of potential screening biomarkers for active TB disease
title_full_unstemmed	A systematic review of potential screening biomarkers for active TB disease
title_sort	systematic review of potential screening biomarkers for active tb disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8c11e9ebacf9483984d791d6efaa2811
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A systematic review of potential screening biomarkers for active TB disease

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