A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteric Yoda1 binding pocket located in the putative mec...

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Autores principales:	Wesley M. Botello-Smith, Wenjuan Jiang, Han Zhang, Alper D. Ozkan, Yi-Chun Lin, Christine N. Pham, Jérôme J. Lacroix, Yun Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c1aeda44ea9466cae5d0b05d2bf2fe1
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spelling	oai:doaj.org-article:8c1aeda44ea9466cae5d0b05d2bf2fe12021-12-02T16:58:28ZA mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda110.1038/s41467-019-12501-12041-1723https://doaj.org/article/8c1aeda44ea9466cae5d0b05d2bf2fe12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12501-1https://doaj.org/toc/2041-1723Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteric Yoda1 binding pocket located in the putative mechanosensory domain.Wesley M. Botello-SmithWenjuan JiangHan ZhangAlper D. OzkanYi-Chun LinChristine N. PhamJérôme J. LacroixYun LuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wesley M. Botello-Smith Wenjuan Jiang Han Zhang Alper D. Ozkan Yi-Chun Lin Christine N. Pham Jérôme J. Lacroix Yun Luo A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
description	Besides mechanical forces, the mechanosensitive channel Piezo1 is activated by the small molecule Yoda1 through an unknown mechanism. Here, using molecular dynamics simulations, calcium imaging and electrophysiology, the authors identify an allosteric Yoda1 binding pocket located in the putative mechanosensory domain.
format	article
author	Wesley M. Botello-Smith Wenjuan Jiang Han Zhang Alper D. Ozkan Yi-Chun Lin Christine N. Pham Jérôme J. Lacroix Yun Luo
author_facet	Wesley M. Botello-Smith Wenjuan Jiang Han Zhang Alper D. Ozkan Yi-Chun Lin Christine N. Pham Jérôme J. Lacroix Yun Luo
author_sort	Wesley M. Botello-Smith
title	A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
title_short	A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
title_full	A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
title_fullStr	A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
title_full_unstemmed	A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1
title_sort	mechanism for the activation of the mechanosensitive piezo1 channel by the small molecule yoda1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8c1aeda44ea9466cae5d0b05d2bf2fe1
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A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

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