Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and nonhuman primates.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8c201057906f4f2d8d990ffb8e12cbae |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8c201057906f4f2d8d990ffb8e12cbae |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8c201057906f4f2d8d990ffb8e12cbae2021-12-02T17:31:43ZAntigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration10.1038/s41467-018-06621-32041-1723https://doaj.org/article/8c201057906f4f2d8d990ffb8e12cbae2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06621-3https://doaj.org/toc/2041-1723Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and nonhuman primates.Amine MelianiFlorence BoisgeraultRomain HardetSolenne MarmierFanny CollaudGiuseppe RonzittiChristian LeborgneHelena Costa VerderaMarcelo Simon SolaSeverine CharlesAlban VignaudLaetitia van WittenbergheGiorgia ManniOlivier ChristopheFrancesca FallarinoChristopher RoyAlicia MichaudPetr IlyinskiiTakashi Kei KishimotoFederico MingozziNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Amine Meliani Florence Boisgerault Romain Hardet Solenne Marmier Fanny Collaud Giuseppe Ronzitti Christian Leborgne Helena Costa Verdera Marcelo Simon Sola Severine Charles Alban Vignaud Laetitia van Wittenberghe Giorgia Manni Olivier Christophe Francesca Fallarino Christopher Roy Alicia Michaud Petr Ilyinskii Takashi Kei Kishimoto Federico Mingozzi Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| description |
Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and nonhuman primates. |
| format |
article |
| author |
Amine Meliani Florence Boisgerault Romain Hardet Solenne Marmier Fanny Collaud Giuseppe Ronzitti Christian Leborgne Helena Costa Verdera Marcelo Simon Sola Severine Charles Alban Vignaud Laetitia van Wittenberghe Giorgia Manni Olivier Christophe Francesca Fallarino Christopher Roy Alicia Michaud Petr Ilyinskii Takashi Kei Kishimoto Federico Mingozzi |
| author_facet |
Amine Meliani Florence Boisgerault Romain Hardet Solenne Marmier Fanny Collaud Giuseppe Ronzitti Christian Leborgne Helena Costa Verdera Marcelo Simon Sola Severine Charles Alban Vignaud Laetitia van Wittenberghe Giorgia Manni Olivier Christophe Francesca Fallarino Christopher Roy Alicia Michaud Petr Ilyinskii Takashi Kei Kishimoto Federico Mingozzi |
| author_sort |
Amine Meliani |
| title |
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| title_short |
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| title_full |
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| title_fullStr |
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| title_full_unstemmed |
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| title_sort |
antigen-selective modulation of aav immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/8c201057906f4f2d8d990ffb8e12cbae |
| work_keys_str_mv |
AT aminemeliani antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT florenceboisgerault antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT romainhardet antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT solennemarmier antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT fannycollaud antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT giusepperonzitti antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT christianleborgne antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT helenacostaverdera antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT marcelosimonsola antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT severinecharles antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT albanvignaud antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT laetitiavanwittenberghe antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT giorgiamanni antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT olivierchristophe antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT francescafallarino antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT christopherroy antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT aliciamichaud antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT petrilyinskii antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT takashikeikishimoto antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration AT federicomingozzi antigenselectivemodulationofaavimmunogenicitywithtolerogenicrapamycinnanoparticlesenablessuccessfulvectorreadministration |
| _version_ |
1718380503920279552 |