Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System

A biomaterial that is both bioactive and capable of controlled drug release is highly attractive for bone regeneration. In previous works, we demonstrated the possibility of combining activated carbon fiber cloth (ACC) and biomimetic apatite (such as calcium-deficient hydroxyapatite (CDA)) to develo...

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Autores principales:	Florian Olivier, Sylvie Bonnamy, Nathalie Rochet, Christophe Drouet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	activated carbon fiber cloth biomimetic apatite adsorption release tetracycline aspirin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8c204f0093ec4aa58a59b8efcf195853
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spelling	oai:doaj.org-article:8c204f0093ec4aa58a59b8efcf1958532021-11-25T17:54:42ZActivated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System10.3390/ijms2222122471422-00671661-6596https://doaj.org/article/8c204f0093ec4aa58a59b8efcf1958532021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12247https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067A biomaterial that is both bioactive and capable of controlled drug release is highly attractive for bone regeneration. In previous works, we demonstrated the possibility of combining activated carbon fiber cloth (ACC) and biomimetic apatite (such as calcium-deficient hydroxyapatite (CDA)) to develop an efficient material for bone regeneration. The aim to use the adsorption properties of an activated carbon/biomimetic apatite composite to synthetize a biomaterial to be used as a controlled drug release system after implantation. The adsorption and desorption of tetracycline and aspirin were first investigated in the ACC and CDA components and then on ACC/CDA composite. The results showed that drug adsorption and release are dependent on the adsorbent material and the drug polarity/hydrophilicity, leading to two distinct modes of drug adsorption and release. Consequently, a double adsorption approach was successfully performed, leading to a multifunctional and innovative ACC-aspirin/CDA-tetracycline implantable biomaterial. In a second step, in vitro tests emphasized a better affinity of the drug (tetracycline or aspirin)-loaded ACC/CDA materials towards human primary osteoblast viability and proliferation. Then, in vivo experiments on a large cortical bone defect in rats was carried out to test biocompatibility and bone regeneration ability. Data clearly highlighted a significant acceleration of bone reconstruction in the presence of the ACC/CDA patch. The ability of the aspirin-loaded ACC/CDA material to release the drug in situ for improving bone healing was also underlined, as a proof of concept. This work highlights the possibility of bone patches with controlled (multi)drug release features being used for bone tissue repair.Florian OlivierSylvie BonnamyNathalie RochetChristophe DrouetMDPI AGarticleactivated carbon fiber clothbiomimetic apatiteadsorptionreleasetetracyclineaspirinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12247, p 12247 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	activated carbon fiber cloth biomimetic apatite adsorption release tetracycline aspirin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	activated carbon fiber cloth biomimetic apatite adsorption release tetracycline aspirin Biology (General) QH301-705.5 Chemistry QD1-999 Florian Olivier Sylvie Bonnamy Nathalie Rochet Christophe Drouet Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
description	A biomaterial that is both bioactive and capable of controlled drug release is highly attractive for bone regeneration. In previous works, we demonstrated the possibility of combining activated carbon fiber cloth (ACC) and biomimetic apatite (such as calcium-deficient hydroxyapatite (CDA)) to develop an efficient material for bone regeneration. The aim to use the adsorption properties of an activated carbon/biomimetic apatite composite to synthetize a biomaterial to be used as a controlled drug release system after implantation. The adsorption and desorption of tetracycline and aspirin were first investigated in the ACC and CDA components and then on ACC/CDA composite. The results showed that drug adsorption and release are dependent on the adsorbent material and the drug polarity/hydrophilicity, leading to two distinct modes of drug adsorption and release. Consequently, a double adsorption approach was successfully performed, leading to a multifunctional and innovative ACC-aspirin/CDA-tetracycline implantable biomaterial. In a second step, in vitro tests emphasized a better affinity of the drug (tetracycline or aspirin)-loaded ACC/CDA materials towards human primary osteoblast viability and proliferation. Then, in vivo experiments on a large cortical bone defect in rats was carried out to test biocompatibility and bone regeneration ability. Data clearly highlighted a significant acceleration of bone reconstruction in the presence of the ACC/CDA patch. The ability of the aspirin-loaded ACC/CDA material to release the drug in situ for improving bone healing was also underlined, as a proof of concept. This work highlights the possibility of bone patches with controlled (multi)drug release features being used for bone tissue repair.
format	article
author	Florian Olivier Sylvie Bonnamy Nathalie Rochet Christophe Drouet
author_facet	Florian Olivier Sylvie Bonnamy Nathalie Rochet Christophe Drouet
author_sort	Florian Olivier
title	Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
title_short	Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
title_full	Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
title_fullStr	Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
title_full_unstemmed	Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System
title_sort	activated carbon fiber cloth/biomimetic apatite: a dual drug delivery system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8c204f0093ec4aa58a59b8efcf195853
work_keys_str_mv	AT florianolivier activatedcarbonfiberclothbiomimeticapatiteadualdrugdeliverysystem AT sylviebonnamy activatedcarbonfiberclothbiomimeticapatiteadualdrugdeliverysystem AT nathalierochet activatedcarbonfiberclothbiomimeticapatiteadualdrugdeliverysystem AT christophedrouet activatedcarbonfiberclothbiomimeticapatiteadualdrugdeliverysystem
_version_	1718411873685078016

Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System

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