IL-1beta promotes the age-associated decline of beta cell function

Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreased in islets, whereas IL-1beta gene expression inc...

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Autores principales:	Marianne Böni-Schnetzler, Hélène Méreau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cell biology Cellular physiology Physiology Science Q
Acceso en línea:	https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c
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spelling	oai:doaj.org-article:8c210037d7104ffebcadf66383ce7f6c2021-11-20T05:08:52ZIL-1beta promotes the age-associated decline of beta cell function2589-004210.1016/j.isci.2021.103250https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012190https://doaj.org/toc/2589-0042Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreased in islets, whereas IL-1beta gene expression increased specifically in the CD45 + islet immune cell fraction. One-year-old mice with a whole-body knockout of IL-1beta had higher insulin secretion in vivo and in isolated islets, along with enhanced proliferation marker Ki67 and elevated size and number of islets. Myeloid cell-specific IL-1beta knockout preserved glucose-stimulated insulin secretion during aging, whereas it declined in control mice. Isolated islets from aged myeloIL-1beta ko mice secreted more insulin along with increased expression of Ins2, Kir6.2, and of the cell-cycle gene E2f1. IL-1beta treatment of isolated islets reduced E2f1, Ins2, and Kir6.2 expression in beta cells. We conclude that IL-1beta contributes the age-associated decline of beta cell function.Marianne Böni-SchnetzlerHélène MéreauLeila RachidSophia J. WiedemannFriederike SchulzeKelly TrimigliozziDaniel T. MeierMarc Y. DonathElsevierarticleCell biologyCellular physiologyPhysiologyScienceQENiScience, Vol 24, Iss 11, Pp 103250- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell biology Cellular physiology Physiology Science Q
spellingShingle	Cell biology Cellular physiology Physiology Science Q Marianne Böni-Schnetzler Hélène Méreau Leila Rachid Sophia J. Wiedemann Friederike Schulze Kelly Trimigliozzi Daniel T. Meier Marc Y. Donath IL-1beta promotes the age-associated decline of beta cell function
description	Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice. During aging, expression of the protective IL-1 receptor antagonist decreased in islets, whereas IL-1beta gene expression increased specifically in the CD45 + islet immune cell fraction. One-year-old mice with a whole-body knockout of IL-1beta had higher insulin secretion in vivo and in isolated islets, along with enhanced proliferation marker Ki67 and elevated size and number of islets. Myeloid cell-specific IL-1beta knockout preserved glucose-stimulated insulin secretion during aging, whereas it declined in control mice. Isolated islets from aged myeloIL-1beta ko mice secreted more insulin along with increased expression of Ins2, Kir6.2, and of the cell-cycle gene E2f1. IL-1beta treatment of isolated islets reduced E2f1, Ins2, and Kir6.2 expression in beta cells. We conclude that IL-1beta contributes the age-associated decline of beta cell function.
format	article
author	Marianne Böni-Schnetzler Hélène Méreau Leila Rachid Sophia J. Wiedemann Friederike Schulze Kelly Trimigliozzi Daniel T. Meier Marc Y. Donath
author_facet	Marianne Böni-Schnetzler Hélène Méreau Leila Rachid Sophia J. Wiedemann Friederike Schulze Kelly Trimigliozzi Daniel T. Meier Marc Y. Donath
author_sort	Marianne Böni-Schnetzler
title	IL-1beta promotes the age-associated decline of beta cell function
title_short	IL-1beta promotes the age-associated decline of beta cell function
title_full	IL-1beta promotes the age-associated decline of beta cell function
title_fullStr	IL-1beta promotes the age-associated decline of beta cell function
title_full_unstemmed	IL-1beta promotes the age-associated decline of beta cell function
title_sort	il-1beta promotes the age-associated decline of beta cell function
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8c210037d7104ffebcadf66383ce7f6c
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IL-1beta promotes the age-associated decline of beta cell function

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