Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

Radioresistance remains a challenge in the treatment of bladder cancer. In this study, the authors show in mice that radiation increases deposits of neutrophil extracellular traps (NETs) via a TLR4-dependent mechanism and that NETs-targeting strategies can improve the response to radiotherapy.

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Autores principales:	Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F. Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c246e604f66445097df274b8e85bffd
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spelling	oai:doaj.org-article:8c246e604f66445097df274b8e85bffd2021-12-02T17:15:21ZRole of neutrophil extracellular traps in radiation resistance of invasive bladder cancer10.1038/s41467-021-23086-z2041-1723https://doaj.org/article/8c246e604f66445097df274b8e85bffd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23086-zhttps://doaj.org/toc/2041-1723Radioresistance remains a challenge in the treatment of bladder cancer. In this study, the authors show in mice that radiation increases deposits of neutrophil extracellular traps (NETs) via a TLR4-dependent mechanism and that NETs-targeting strategies can improve the response to radiotherapy.Surashri Shinde-JadhavJose Joao MansureRoni F. RayesGautier MarcqMina AyoubRodrigo SkowronskiRonald KoolFrance BourdeauFadi BrimoJonathan SpicerWassim KassoufNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Surashri Shinde-Jadhav Jose Joao Mansure Roni F. Rayes Gautier Marcq Mina Ayoub Rodrigo Skowronski Ronald Kool France Bourdeau Fadi Brimo Jonathan Spicer Wassim Kassouf Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
description	Radioresistance remains a challenge in the treatment of bladder cancer. In this study, the authors show in mice that radiation increases deposits of neutrophil extracellular traps (NETs) via a TLR4-dependent mechanism and that NETs-targeting strategies can improve the response to radiotherapy.
format	article
author	Surashri Shinde-Jadhav Jose Joao Mansure Roni F. Rayes Gautier Marcq Mina Ayoub Rodrigo Skowronski Ronald Kool France Bourdeau Fadi Brimo Jonathan Spicer Wassim Kassouf
author_facet	Surashri Shinde-Jadhav Jose Joao Mansure Roni F. Rayes Gautier Marcq Mina Ayoub Rodrigo Skowronski Ronald Kool France Bourdeau Fadi Brimo Jonathan Spicer Wassim Kassouf
author_sort	Surashri Shinde-Jadhav
title	Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
title_short	Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
title_full	Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
title_fullStr	Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
title_full_unstemmed	Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
title_sort	role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c246e604f66445097df274b8e85bffd
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Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

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