Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal

Without understanding the genetic architecture of inbreeding depression, its effects are hard to pinpoint. Long-term data from wild Soay sheep shows that inbreeding manifests in long runs of homozygosity, which made up nearly half of the genome in the most inbred individuals with severe fitness cons...

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Bibliographic Details
Main Authors: M. A. Stoffel, S. E. Johnston, J. G. Pilkington, J. M. Pemberton
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/8c27a50261724d00ae93f0b527c6d79c
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Summary:Without understanding the genetic architecture of inbreeding depression, its effects are hard to pinpoint. Long-term data from wild Soay sheep shows that inbreeding manifests in long runs of homozygosity, which made up nearly half of the genome in the most inbred individuals with severe fitness consequences.