IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS

Abstract. Macrophages are among key players of inflammatory events, acquiring either pro-inflammatory M1, or anti-inflammatory M2 phenotype, dependent on their microenvironment. Some endogenous macrophagereprogramming factors (MRFs), e.g., TGF-β (an M2-inducing agent), are found in blood serum. This...

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Autores principales:	S. V. Kruglov, S. V. Lyamina, T. Yu. Vedenikin, O. A. Borodovizyna, I. A. Suvorova, Sh. L. Shimshelashvili, I. Yu. Malyshev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	reprogramming macrophages phenotype nitric oxide Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8c2936a189624bf6a5a273d24a29c3a9
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spelling	oai:doaj.org-article:8c2936a189624bf6a5a273d24a29c3a92021-11-18T08:03:40ZIN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS1563-06252313-741X10.15789/1563-0625-2012-1-2-127-132https://doaj.org/article/8c2936a189624bf6a5a273d24a29c3a92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/310https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Macrophages are among key players of inflammatory events, acquiring either pro-inflammatory M1, or anti-inflammatory M2 phenotype, dependent on their microenvironment. Some endogenous macrophagereprogramming factors (MRFs), e.g., TGF-β (an M2-inducing agent), are found in blood serum. This work confirms a hypothesis on in vitro M1-to-M2 phenotype reprogramming of cultured macrophages, by means of decrease or increase in serum concentration. Noteworthy, the macrophages from C57BL/6 и BALB/c mice strains did not differ with their reprogramming capacity. In general, our results allow of extending present knowledge about a role of environmental factors in regulation of macrophage activities.S. V. KruglovS. V. LyaminaT. Yu. VedenikinO. A. BorodovizynaI. A. SuvorovaSh. L. ShimshelashviliI. Yu. MalyshevSPb RAACIarticlereprogrammingmacrophagesphenotypenitric oxideImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 127-132 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	reprogramming macrophages phenotype nitric oxide Immunologic diseases. Allergy RC581-607
spellingShingle	reprogramming macrophages phenotype nitric oxide Immunologic diseases. Allergy RC581-607 S. V. Kruglov S. V. Lyamina T. Yu. Vedenikin O. A. Borodovizyna I. A. Suvorova Sh. L. Shimshelashvili I. Yu. Malyshev IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
description	Abstract. Macrophages are among key players of inflammatory events, acquiring either pro-inflammatory M1, or anti-inflammatory M2 phenotype, dependent on their microenvironment. Some endogenous macrophagereprogramming factors (MRFs), e.g., TGF-β (an M2-inducing agent), are found in blood serum. This work confirms a hypothesis on in vitro M1-to-M2 phenotype reprogramming of cultured macrophages, by means of decrease or increase in serum concentration. Noteworthy, the macrophages from C57BL/6 и BALB/c mice strains did not differ with their reprogramming capacity. In general, our results allow of extending present knowledge about a role of environmental factors in regulation of macrophage activities.
format	article
author	S. V. Kruglov S. V. Lyamina T. Yu. Vedenikin O. A. Borodovizyna I. A. Suvorova Sh. L. Shimshelashvili I. Yu. Malyshev
author_facet	S. V. Kruglov S. V. Lyamina T. Yu. Vedenikin O. A. Borodovizyna I. A. Suvorova Sh. L. Shimshelashvili I. Yu. Malyshev
author_sort	S. V. Kruglov
title	IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
title_short	IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
title_full	IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
title_fullStr	IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
title_full_unstemmed	IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS
title_sort	in vitro reprogramming of nitric oxide-synthetic mechanisms for m1 and m2 phenotypes of murine peritoneal macrophages: dependence on different serum concentrations
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8c2936a189624bf6a5a273d24a29c3a9
work_keys_str_mv	AT svkruglov invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT svlyamina invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT tyuvedenikin invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT oaborodovizyna invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT iasuvorova invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT shlshimshelashvili invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations AT iyumalyshev invitroreprogrammingofnitricoxidesyntheticmechanismsform1andm2phenotypesofmurineperitonealmacrophagesdependenceondifferentserumconcentrations
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IN VITRO REPROGRAMMING OF NITRIC OXIDE-SYNTHETIC MECHANISMS FOR M1 AND M2 PHENOTYPES OF MURINE PERITONEAL MACROPHAGES: DEPENDENCE ON DIFFERENT SERUM CONCENTRATIONS

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