Comparing right- and left sided injection-drug related infective endocarditis

Abstract The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis betwe...

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Autores principales:	Allan Clarelin, Magnus Rasmussen, Lars Olaison, Sigurdur Ragnarsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c29b7bdd412494f9841dd51b9146eb0
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spelling	oai:doaj.org-article:8c29b7bdd412494f9841dd51b9146eb02021-12-02T14:01:35ZComparing right- and left sided injection-drug related infective endocarditis10.1038/s41598-020-80869-y2045-2322https://doaj.org/article/8c29b7bdd412494f9841dd51b9146eb02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80869-yhttps://doaj.org/toc/2045-2322Abstract The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conducted. A total of 586 people with IDU-IE were identified and divided into left-sided (n = 204) and right-sided (n = 382) IE. Descriptive statistics, Cox-regression and Kaplan–Meier survival estimates were used. The mean age of patients in the left-sided group was 46 years compared to 35 years in the right-sided group, p < 0.001. Left-sided IE had a higher proportion of females. Staphylococcus aureus was the causative pathogen in 48% of cases in the left-sided group compared to 88% in the right-sided group. Unadjusted and adjusted long-term survival was better in right-sided IE compared to left-sided IE. Independent predictors of long-term mortality were increasing age, end-stage renal disease, nosocomial infection, brain emboli and left-sided IE. Left-sided IE was common in people with IDU but the proportion of females with left-sided IE was low. S. aureus was twice as common in right-sided IE compared to left-sided IE, and the long-term prognosis of right sided IDU-associated IE was better compared to left-sided IE despite the fact that few were operated.Allan ClarelinMagnus RasmussenLars OlaisonSigurdur RagnarssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allan Clarelin Magnus Rasmussen Lars Olaison Sigurdur Ragnarsson Comparing right- and left sided injection-drug related infective endocarditis
description	Abstract The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conducted. A total of 586 people with IDU-IE were identified and divided into left-sided (n = 204) and right-sided (n = 382) IE. Descriptive statistics, Cox-regression and Kaplan–Meier survival estimates were used. The mean age of patients in the left-sided group was 46 years compared to 35 years in the right-sided group, p < 0.001. Left-sided IE had a higher proportion of females. Staphylococcus aureus was the causative pathogen in 48% of cases in the left-sided group compared to 88% in the right-sided group. Unadjusted and adjusted long-term survival was better in right-sided IE compared to left-sided IE. Independent predictors of long-term mortality were increasing age, end-stage renal disease, nosocomial infection, brain emboli and left-sided IE. Left-sided IE was common in people with IDU but the proportion of females with left-sided IE was low. S. aureus was twice as common in right-sided IE compared to left-sided IE, and the long-term prognosis of right sided IDU-associated IE was better compared to left-sided IE despite the fact that few were operated.
format	article
author	Allan Clarelin Magnus Rasmussen Lars Olaison Sigurdur Ragnarsson
author_facet	Allan Clarelin Magnus Rasmussen Lars Olaison Sigurdur Ragnarsson
author_sort	Allan Clarelin
title	Comparing right- and left sided injection-drug related infective endocarditis
title_short	Comparing right- and left sided injection-drug related infective endocarditis
title_full	Comparing right- and left sided injection-drug related infective endocarditis
title_fullStr	Comparing right- and left sided injection-drug related infective endocarditis
title_full_unstemmed	Comparing right- and left sided injection-drug related infective endocarditis
title_sort	comparing right- and left sided injection-drug related infective endocarditis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c29b7bdd412494f9841dd51b9146eb0
work_keys_str_mv	AT allanclarelin comparingrightandleftsidedinjectiondrugrelatedinfectiveendocarditis AT magnusrasmussen comparingrightandleftsidedinjectiondrugrelatedinfectiveendocarditis AT larsolaison comparingrightandleftsidedinjectiondrugrelatedinfectiveendocarditis AT sigurdurragnarsson comparingrightandleftsidedinjectiondrugrelatedinfectiveendocarditis
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Comparing right- and left sided injection-drug related infective endocarditis

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