Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhibitors might help reducing resistance development

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Autores principales:	Zhizeng Sun, Liya Hu, Banumathi Sankaran, B. V. Venkataram Prasad, Timothy Palzkill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c2aae0dbe0a437bb3b03635d51701e9
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spelling	oai:doaj.org-article:8c2aae0dbe0a437bb3b03635d51701e92021-12-02T15:33:33ZDifferential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics10.1038/s41467-018-06839-12041-1723https://doaj.org/article/8c2aae0dbe0a437bb3b03635d51701e92018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06839-1https://doaj.org/toc/2041-1723The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhibitors might help reducing resistance developmentZhizeng SunLiya HuBanumathi SankaranB. V. Venkataram PrasadTimothy PalzkillNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhizeng Sun Liya Hu Banumathi Sankaran B. V. Venkataram Prasad Timothy Palzkill Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
description	The NDM-1 β-lactamase confers resistance to most β-lactam antibiotics. By functional analysis of residues required for hydrolysis, Sun et al. reveal stringent sequence constraints for carbapenems, suggesting that specific combinations of NDM-1 inhibitors might help reducing resistance development
format	article
author	Zhizeng Sun Liya Hu Banumathi Sankaran B. V. Venkataram Prasad Timothy Palzkill
author_facet	Zhizeng Sun Liya Hu Banumathi Sankaran B. V. Venkataram Prasad Timothy Palzkill
author_sort	Zhizeng Sun
title	Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
title_short	Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
title_full	Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
title_fullStr	Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
title_full_unstemmed	Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
title_sort	differential active site requirements for ndm-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8c2aae0dbe0a437bb3b03635d51701e9
work_keys_str_mv	AT zhizengsun differentialactivesiterequirementsforndm1blactamasehydrolysisofcarbapenemversuspenicillinandcephalosporinantibiotics AT liyahu differentialactivesiterequirementsforndm1blactamasehydrolysisofcarbapenemversuspenicillinandcephalosporinantibiotics AT banumathisankaran differentialactivesiterequirementsforndm1blactamasehydrolysisofcarbapenemversuspenicillinandcephalosporinantibiotics AT bvvenkataramprasad differentialactivesiterequirementsforndm1blactamasehydrolysisofcarbapenemversuspenicillinandcephalosporinantibiotics AT timothypalzkill differentialactivesiterequirementsforndm1blactamasehydrolysisofcarbapenemversuspenicillinandcephalosporinantibiotics
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Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

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