Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

Smad3, a transcription factor activated by TGF-β, has been implicated in tumorigenesis. Here the authors show that Smad3 inhibits NK cell differentiation and effector function by repressing NFIL3, and that genetic or pharmacological blockade of Smad3 expands tumour-suppressive NK cells and restricts...

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Autores principales: Patrick Ming-Kuen Tang, Shuang Zhou, Xiao-Ming Meng, Qing-Ming Wang, Chun-Jie Li, Guang-Yu Lian, Xiao-Ru Huang, Yong-Jiang Tang, Xin-Yuan Guan, Bryan Ping-Yen Yan, Ka-Fai To, Hui-Yao Lan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8c2b4301337a42d6ac52c6dbfc481a28
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spelling oai:doaj.org-article:8c2b4301337a42d6ac52c6dbfc481a282021-12-02T15:38:51ZSmad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development10.1038/ncomms146772041-1723https://doaj.org/article/8c2b4301337a42d6ac52c6dbfc481a282017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14677https://doaj.org/toc/2041-1723Smad3, a transcription factor activated by TGF-β, has been implicated in tumorigenesis. Here the authors show that Smad3 inhibits NK cell differentiation and effector function by repressing NFIL3, and that genetic or pharmacological blockade of Smad3 expands tumour-suppressive NK cells and restricts tumour growth in mice.Patrick Ming-Kuen TangShuang ZhouXiao-Ming MengQing-Ming WangChun-Jie LiGuang-Yu LianXiao-Ru HuangYong-Jiang TangXin-Yuan GuanBryan Ping-Yen YanKa-Fai ToHui-Yao LanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Patrick Ming-Kuen Tang
Shuang Zhou
Xiao-Ming Meng
Qing-Ming Wang
Chun-Jie Li
Guang-Yu Lian
Xiao-Ru Huang
Yong-Jiang Tang
Xin-Yuan Guan
Bryan Ping-Yen Yan
Ka-Fai To
Hui-Yao Lan
Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
description Smad3, a transcription factor activated by TGF-β, has been implicated in tumorigenesis. Here the authors show that Smad3 inhibits NK cell differentiation and effector function by repressing NFIL3, and that genetic or pharmacological blockade of Smad3 expands tumour-suppressive NK cells and restricts tumour growth in mice.
format article
author Patrick Ming-Kuen Tang
Shuang Zhou
Xiao-Ming Meng
Qing-Ming Wang
Chun-Jie Li
Guang-Yu Lian
Xiao-Ru Huang
Yong-Jiang Tang
Xin-Yuan Guan
Bryan Ping-Yen Yan
Ka-Fai To
Hui-Yao Lan
author_facet Patrick Ming-Kuen Tang
Shuang Zhou
Xiao-Ming Meng
Qing-Ming Wang
Chun-Jie Li
Guang-Yu Lian
Xiao-Ru Huang
Yong-Jiang Tang
Xin-Yuan Guan
Bryan Ping-Yen Yan
Ka-Fai To
Hui-Yao Lan
author_sort Patrick Ming-Kuen Tang
title Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
title_short Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
title_full Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
title_fullStr Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
title_full_unstemmed Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
title_sort smad3 promotes cancer progression by inhibiting e4bp4-mediated nk cell development
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8c2b4301337a42d6ac52c6dbfc481a28
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