Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury

The regeneration dynamics following peripheral nerve injury differs among species. Here, the authors compared transcriptomic and lipid metabolism changes in murine and human Schwann cells in vivo and ex vivo sural nerves, underlying their switch from myelinating to repair state following injury.

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Autores principales: Sofia Meyer zu Reckendorf, Christine Brand, Maria T. Pedro, Jutta Hegler, Corinna S. Schilling, Raissa Lerner, Laura Bindila, Gregor Antoniadis, Bernd Knöll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8c2c6448c4ef49c4819a929191ec28cb
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Sumario:The regeneration dynamics following peripheral nerve injury differs among species. Here, the authors compared transcriptomic and lipid metabolism changes in murine and human Schwann cells in vivo and ex vivo sural nerves, underlying their switch from myelinating to repair state following injury.