Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study

ObjectiveThis study aimed to explore the value of elasticity score (ES) and strain ratio (SR) combined with conventional ultrasound in distinguishing benign and malignant breast masses and reducing biopsy of BI-RADS (Breast Imaging Reporting and Data System) 4a lesions.MethodsThis prospective, multi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qi Wei, Yu-Jing Yan, Ge-Ge Wu, Xi-Rong Ye, Fan Jiang, Jie Liu, Gang Wang, Yi Wang, Yu Wang, Zhi-Ping Pan, Jin-Hua Hu, Juan Song, Christoph F. Dietrich, Xin-Wu Cui
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	strain elastography elasticity score strain ratio ultrasound breast masses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8c2cf83cd3ad4c9096e7f412b39902bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c2cf83cd3ad4c9096e7f412b39902bd
record_format	dspace
spelling	oai:doaj.org-article:8c2cf83cd3ad4c9096e7f412b39902bd2021-11-09T11:12:09ZAdded Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study2234-943X10.3389/fonc.2021.779612https://doaj.org/article/8c2cf83cd3ad4c9096e7f412b39902bd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.779612/fullhttps://doaj.org/toc/2234-943XObjectiveThis study aimed to explore the value of elasticity score (ES) and strain ratio (SR) combined with conventional ultrasound in distinguishing benign and malignant breast masses and reducing biopsy of BI-RADS (Breast Imaging Reporting and Data System) 4a lesions.MethodsThis prospective, multicenter study included 910 patients from nine different hospitals. The acquisition and analysis of conventional ultrasound and strain elastography (SE) were obtained by radiologists with more than 5 years of experience in breast ultrasound imaging. The diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under curve (AUC) of conventional ultrasound alone and combined tests with ES and/or SR were calculated and compared.ResultsThe optimal cutoff value of SR for differentiating benign from malignant masses was 2.27, with a sensitivity of 60.2% and a specificity of 84.8%. When combined with ES and SR, the AUC of the new BI-RADS classification increased from 0.733 to 0.824 (p < 0.001); the specificity increased from 48.1% to 68.5% (p < 0.001) without a decrease in the sensitivity (98.5% vs. 96.4%, p = 0.065); and the PPV increased from 52.2% to 63.7% (p < 0.001) without a loss in the NPV (98.2% vs. 97.1%, p = 0.327). All three combinations of conventional ultrasound, ES, and SR could reduce the biopsy rate of category 4a lesions without reducing the malignant rate of biopsy (from 100% to 68.3%, 34.9%, and 50.4%, respectively, all p < 0.001).ConclusionsSE can be used as a useful and non-invasive additional method to improve the diagnostic performance of conventional ultrasound by increasing AUC and specificity and reducing the unnecessary biopsy of BI-RADS 4a lesions.Qi WeiYu-Jing YanGe-Ge WuXi-Rong YeFan JiangJie LiuGang WangYi WangYu WangZhi-Ping PanJin-Hua HuJuan SongChristoph F. DietrichXin-Wu CuiFrontiers Media S.A.articlestrain elastographyelasticity scorestrain ratioultrasoundbreast massesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	strain elastography elasticity score strain ratio ultrasound breast masses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	strain elastography elasticity score strain ratio ultrasound breast masses Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Qi Wei Yu-Jing Yan Ge-Ge Wu Xi-Rong Ye Fan Jiang Jie Liu Gang Wang Yi Wang Yu Wang Zhi-Ping Pan Jin-Hua Hu Juan Song Christoph F. Dietrich Xin-Wu Cui Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
description	ObjectiveThis study aimed to explore the value of elasticity score (ES) and strain ratio (SR) combined with conventional ultrasound in distinguishing benign and malignant breast masses and reducing biopsy of BI-RADS (Breast Imaging Reporting and Data System) 4a lesions.MethodsThis prospective, multicenter study included 910 patients from nine different hospitals. The acquisition and analysis of conventional ultrasound and strain elastography (SE) were obtained by radiologists with more than 5 years of experience in breast ultrasound imaging. The diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under curve (AUC) of conventional ultrasound alone and combined tests with ES and/or SR were calculated and compared.ResultsThe optimal cutoff value of SR for differentiating benign from malignant masses was 2.27, with a sensitivity of 60.2% and a specificity of 84.8%. When combined with ES and SR, the AUC of the new BI-RADS classification increased from 0.733 to 0.824 (p < 0.001); the specificity increased from 48.1% to 68.5% (p < 0.001) without a decrease in the sensitivity (98.5% vs. 96.4%, p = 0.065); and the PPV increased from 52.2% to 63.7% (p < 0.001) without a loss in the NPV (98.2% vs. 97.1%, p = 0.327). All three combinations of conventional ultrasound, ES, and SR could reduce the biopsy rate of category 4a lesions without reducing the malignant rate of biopsy (from 100% to 68.3%, 34.9%, and 50.4%, respectively, all p < 0.001).ConclusionsSE can be used as a useful and non-invasive additional method to improve the diagnostic performance of conventional ultrasound by increasing AUC and specificity and reducing the unnecessary biopsy of BI-RADS 4a lesions.
format	article
author	Qi Wei Yu-Jing Yan Ge-Ge Wu Xi-Rong Ye Fan Jiang Jie Liu Gang Wang Yi Wang Yu Wang Zhi-Ping Pan Jin-Hua Hu Juan Song Christoph F. Dietrich Xin-Wu Cui
author_facet	Qi Wei Yu-Jing Yan Ge-Ge Wu Xi-Rong Ye Fan Jiang Jie Liu Gang Wang Yi Wang Yu Wang Zhi-Ping Pan Jin-Hua Hu Juan Song Christoph F. Dietrich Xin-Wu Cui
author_sort	Qi Wei
title	Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
title_short	Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
title_full	Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
title_fullStr	Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
title_full_unstemmed	Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study
title_sort	added value of a new strain elastography technique in conventional ultrasound for the diagnosis of breast masses: a prospective multicenter study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8c2cf83cd3ad4c9096e7f412b39902bd
work_keys_str_mv	AT qiwei addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT yujingyan addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT gegewu addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT xirongye addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT fanjiang addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT jieliu addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT gangwang addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT yiwang addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT yuwang addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT zhipingpan addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT jinhuahu addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT juansong addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT christophfdietrich addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy AT xinwucui addedvalueofanewstrainelastographytechniqueinconventionalultrasoundforthediagnosisofbreastmassesaprospectivemulticenterstudy
_version_	1718441126952697856

Added Value of a New Strain Elastography Technique in Conventional Ultrasound for the Diagnosis of Breast Masses: A Prospective Multicenter Study

Ejemplares similares