Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option?
Background: The standard treatment for adenoid cystic carcinoma of the head and neck is surgical resection followed by postoperative radiotherapy (PORT). Currently, definitive radiotherapy (defRT) is considered an inadequate treatment; however, its data are based on studies using classical radiother...
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2021
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oai:doaj.org-article:8c2d0396665c49b693e0852e7f85a3472021-11-11T15:33:47ZComparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option?10.3390/cancers132155072072-6694https://doaj.org/article/8c2d0396665c49b693e0852e7f85a3472021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5507https://doaj.org/toc/2072-6694Background: The standard treatment for adenoid cystic carcinoma of the head and neck is surgical resection followed by postoperative radiotherapy (PORT). Currently, definitive radiotherapy (defRT) is considered an inadequate treatment; however, its data are based on studies using classical radiotherapy techniques. Therefore, the therapeutic effects of current radiotherapy techniques have not been adequately evaluated, and it may have underestimated the efficacy of defRT. Methods: We retrospectively analyzed 44 adenoid cystic carcinoma patients treated with radiotherapy based on modern treatment techniques from 1993 to 2017. Results: Twenty-four patients underwent PORT and 20 patients underwent defRT. The 5-year overall survival rates for patients treated with PORT and defRT were 85.3% and 79.7%, respectively. The 5-year local control rates were 82.5% and 83.1%, respectively. There were no statistically significant differences in the overall survival and local control of patients treated with PORT and defRT (<i>p</i> = 0.4392 and <i>p</i> = 0.0904, respectively). Conclusion: Our results show that defRT is comparable to surgical resection followed by PORT with respect to overall survival and local control. The results suggest that defRT can be an effective treatment option for adenoid cystic carcinoma of the head and neck.Nobutaka MizoguchiKio KanoSatoshi ShimaKeisuke TsuchidaYosuke TakakusagiItsuko SerizawaKeiko AkahaneMasahiro KawaharaManatsu YoshidaYuka KitaniKaori HashimotoMadoka FurukawaTadashi KamadaHiroyuki KatohDaisaku YoshidaKatsuyuki ShiraiMDPI AGarticleadenoid cystic carcinomahead and neck cancerdefinitive radiotherapypostoperative radiotherapysurgical resectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5507, p 5507 (2021) |
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| topic |
adenoid cystic carcinoma head and neck cancer definitive radiotherapy postoperative radiotherapy surgical resection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
adenoid cystic carcinoma head and neck cancer definitive radiotherapy postoperative radiotherapy surgical resection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nobutaka Mizoguchi Kio Kano Satoshi Shima Keisuke Tsuchida Yosuke Takakusagi Itsuko Serizawa Keiko Akahane Masahiro Kawahara Manatsu Yoshida Yuka Kitani Kaori Hashimoto Madoka Furukawa Tadashi Kamada Hiroyuki Katoh Daisaku Yoshida Katsuyuki Shirai Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| description |
Background: The standard treatment for adenoid cystic carcinoma of the head and neck is surgical resection followed by postoperative radiotherapy (PORT). Currently, definitive radiotherapy (defRT) is considered an inadequate treatment; however, its data are based on studies using classical radiotherapy techniques. Therefore, the therapeutic effects of current radiotherapy techniques have not been adequately evaluated, and it may have underestimated the efficacy of defRT. Methods: We retrospectively analyzed 44 adenoid cystic carcinoma patients treated with radiotherapy based on modern treatment techniques from 1993 to 2017. Results: Twenty-four patients underwent PORT and 20 patients underwent defRT. The 5-year overall survival rates for patients treated with PORT and defRT were 85.3% and 79.7%, respectively. The 5-year local control rates were 82.5% and 83.1%, respectively. There were no statistically significant differences in the overall survival and local control of patients treated with PORT and defRT (<i>p</i> = 0.4392 and <i>p</i> = 0.0904, respectively). Conclusion: Our results show that defRT is comparable to surgical resection followed by PORT with respect to overall survival and local control. The results suggest that defRT can be an effective treatment option for adenoid cystic carcinoma of the head and neck. |
| format |
article |
| author |
Nobutaka Mizoguchi Kio Kano Satoshi Shima Keisuke Tsuchida Yosuke Takakusagi Itsuko Serizawa Keiko Akahane Masahiro Kawahara Manatsu Yoshida Yuka Kitani Kaori Hashimoto Madoka Furukawa Tadashi Kamada Hiroyuki Katoh Daisaku Yoshida Katsuyuki Shirai |
| author_facet |
Nobutaka Mizoguchi Kio Kano Satoshi Shima Keisuke Tsuchida Yosuke Takakusagi Itsuko Serizawa Keiko Akahane Masahiro Kawahara Manatsu Yoshida Yuka Kitani Kaori Hashimoto Madoka Furukawa Tadashi Kamada Hiroyuki Katoh Daisaku Yoshida Katsuyuki Shirai |
| author_sort |
Nobutaka Mizoguchi |
| title |
Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| title_short |
Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| title_full |
Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| title_fullStr |
Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| title_full_unstemmed |
Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? |
| title_sort |
comparison of clinical outcomes of definitive and postoperative radiotherapy for adenoid cystic carcinoma of the head and neck: can definitive radiotherapy be a treatment option? |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/8c2d0396665c49b693e0852e7f85a347 |
| work_keys_str_mv |
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