Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure

Objective: The aim of this study was to analyze whether V̇O2-kinetics during cardiopulmonary exercise testing (CPET) is a useful marker for the diagnosis of heart failure (HF) and to determine which V̇O2-kinetic parameter distinguishes healthy participants and patients with HF.Methods: A total of 52...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonathan Wagner, Max Niemeyer, Denis Infanger, Otmar Pfister, Jonathan Myers, Arno Schmidt-Trucksäss, Raphael Knaier
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	V̇O2max V̇O2-kinetics CRF risk stratification heart failure Physiology QP1-981
Acceso en línea:	https://doaj.org/article/8c2d8afbc90043bbb91c318a6a5c35ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c2d8afbc90043bbb91c318a6a5c35ea
record_format	dspace
spelling	oai:doaj.org-article:8c2d8afbc90043bbb91c318a6a5c35ea2021-12-01T01:48:31ZComparison of V̇O2-Kinetic Parameters for the Management of Heart Failure1664-042X10.3389/fphys.2021.775601https://doaj.org/article/8c2d8afbc90043bbb91c318a6a5c35ea2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.775601/fullhttps://doaj.org/toc/1664-042XObjective: The aim of this study was to analyze whether V̇O2-kinetics during cardiopulmonary exercise testing (CPET) is a useful marker for the diagnosis of heart failure (HF) and to determine which V̇O2-kinetic parameter distinguishes healthy participants and patients with HF.Methods: A total of 526 healthy participants and 79 patients with HF between 20 and 90 years of age performed a CPET. The CPET was preceded by a 3-min low-intensity warm-up and followed by a 3-min recovery bout. V̇O2-kinetics was calculated from the rest to exercise transition of the warm-up bout (on-kinetics), from the exercise to recovery transition following ramp test termination (off-kinetics) and from the initial delay of V̇O2 during the warm-up to ramp test transition (ramp-kinetics).Results: V̇O2 off-kinetics showed the highest z-score differences between healthy participants and patients with HF. Furthermore, off-kinetics was strongly associated with V̇O2peak. In contrast, ramp-kinetics and on-kinetics showed only minimal z-score differences between healthy participants and patients with HF. The best on- and off-kinetic parameters significantly improved a model to predict the disease severity. However, there was no relevant additional value of V̇O2-kinetics when V̇O2peak was part of the model.Conclusion: V̇O2 off-kinetics appears to be superior for distinguishing patients with HF and healthy participants compared with V̇O2 on-kinetics and ramp-kinetics. If V̇O2peak cannot be determined, V̇O2 off-kinetics provides an acceptable substitute. However, the additional value beyond that of V̇O2peak cannot be provided by V̇O2-kinetics.Jonathan WagnerMax NiemeyerDenis InfangerOtmar PfisterJonathan MyersArno Schmidt-TrucksässRaphael KnaierFrontiers Media S.A.articleV̇O2maxV̇O2-kineticsCRFrisk stratificationheart failurePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	V̇O2max V̇O2-kinetics CRF risk stratification heart failure Physiology QP1-981
spellingShingle	V̇O2max V̇O2-kinetics CRF risk stratification heart failure Physiology QP1-981 Jonathan Wagner Max Niemeyer Denis Infanger Otmar Pfister Jonathan Myers Arno Schmidt-Trucksäss Raphael Knaier Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
description	Objective: The aim of this study was to analyze whether V̇O2-kinetics during cardiopulmonary exercise testing (CPET) is a useful marker for the diagnosis of heart failure (HF) and to determine which V̇O2-kinetic parameter distinguishes healthy participants and patients with HF.Methods: A total of 526 healthy participants and 79 patients with HF between 20 and 90 years of age performed a CPET. The CPET was preceded by a 3-min low-intensity warm-up and followed by a 3-min recovery bout. V̇O2-kinetics was calculated from the rest to exercise transition of the warm-up bout (on-kinetics), from the exercise to recovery transition following ramp test termination (off-kinetics) and from the initial delay of V̇O2 during the warm-up to ramp test transition (ramp-kinetics).Results: V̇O2 off-kinetics showed the highest z-score differences between healthy participants and patients with HF. Furthermore, off-kinetics was strongly associated with V̇O2peak. In contrast, ramp-kinetics and on-kinetics showed only minimal z-score differences between healthy participants and patients with HF. The best on- and off-kinetic parameters significantly improved a model to predict the disease severity. However, there was no relevant additional value of V̇O2-kinetics when V̇O2peak was part of the model.Conclusion: V̇O2 off-kinetics appears to be superior for distinguishing patients with HF and healthy participants compared with V̇O2 on-kinetics and ramp-kinetics. If V̇O2peak cannot be determined, V̇O2 off-kinetics provides an acceptable substitute. However, the additional value beyond that of V̇O2peak cannot be provided by V̇O2-kinetics.
format	article
author	Jonathan Wagner Max Niemeyer Denis Infanger Otmar Pfister Jonathan Myers Arno Schmidt-Trucksäss Raphael Knaier
author_facet	Jonathan Wagner Max Niemeyer Denis Infanger Otmar Pfister Jonathan Myers Arno Schmidt-Trucksäss Raphael Knaier
author_sort	Jonathan Wagner
title	Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
title_short	Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
title_full	Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
title_fullStr	Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
title_full_unstemmed	Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure
title_sort	comparison of v̇o2-kinetic parameters for the management of heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8c2d8afbc90043bbb91c318a6a5c35ea
work_keys_str_mv	AT jonathanwagner comparisonofvo2kineticparametersforthemanagementofheartfailure AT maxniemeyer comparisonofvo2kineticparametersforthemanagementofheartfailure AT denisinfanger comparisonofvo2kineticparametersforthemanagementofheartfailure AT otmarpfister comparisonofvo2kineticparametersforthemanagementofheartfailure AT jonathanmyers comparisonofvo2kineticparametersforthemanagementofheartfailure AT arnoschmidttrucksass comparisonofvo2kineticparametersforthemanagementofheartfailure AT raphaelknaier comparisonofvo2kineticparametersforthemanagementofheartfailure
_version_	1718405973923594240

Comparison of V̇O2-Kinetic Parameters for the Management of Heart Failure

Ejemplares similares