Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date. Here, the authors develop a more efficient approach to generate these antibodies, and demonstrate their potential in research and therapeutic applications.

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Detalles Bibliográficos
Autores principales: Justin A. Spanier, Daniel R. Frederick, Justin J. Taylor, James R. Heffernan, Dmitri I. Kotov, Tijana Martinov, Kevin C. Osum, Jenna L. Ruggiero, Blake J. Rust, Samuel J. Landry, Marc K. Jenkins, James B. McLachlan, Brian T. Fife
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8c2e27eaab1b4cc89a8d7d85fe9db231
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Descripción
Sumario:Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date. Here, the authors develop a more efficient approach to generate these antibodies, and demonstrate their potential in research and therapeutic applications.

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