Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment

Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date. Here, the authors develop a more efficient approach to generate these antibodies, and demonstrate their potential in research and therapeutic applications.

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Auteurs principaux: Justin A. Spanier, Daniel R. Frederick, Justin J. Taylor, James R. Heffernan, Dmitri I. Kotov, Tijana Martinov, Kevin C. Osum, Jenna L. Ruggiero, Blake J. Rust, Samuel J. Landry, Marc K. Jenkins, James B. McLachlan, Brian T. Fife
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Science
Q
Accès en ligne:https://doaj.org/article/8c2e27eaab1b4cc89a8d7d85fe9db231
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Résumé:Generating antibodies specific for the peptide–MHCII complexes has been challenging, with only a handful made to date. Here, the authors develop a more efficient approach to generate these antibodies, and demonstrate their potential in research and therapeutic applications.

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