Clinical implementetion of vildagliptin: data from recent studies comparing incretin-based medications

The introduction of DPP-4 inhibitors substantially increased therapeutic options for type 2 diabetes mellitus (T2DM). The unique mechanism of action allows using these agents both as monotherapy and in combination with conventional anti-diabetes drugs. Evidence base for efficacy and safety of DPP-4...

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Autor principal: Elena Valer'evna Biryukova
Formato: article
Lenguaje:EN
RU
Publicado: Endocrinology Research Centre 2014
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Acceso en línea:https://doaj.org/article/8c30a6a6702c497f943e2333951c8c6a
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Sumario:The introduction of DPP-4 inhibitors substantially increased therapeutic options for type 2 diabetes mellitus (T2DM). The unique mechanism of action allows using these agents both as monotherapy and in combination with conventional anti-diabetes drugs. Evidence base for efficacy and safety of DPP-4 inhibitors deepens every year, but to date only a few studies addressed direct comparison between individual agents within this pharmacological class. Current article presents data from the studies comparing vildagliptin with other DPP-4 inhibitors, as well as GLP-1 agonists.