Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission

Karan Seegobin,1 Muhamad Alhaj Moustafa,1 Liuyan Jiang,2 Han W Tun1 1Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USA; 2Department of Pathology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USACorrespondence: Karan SeegobinDepartment of He...

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Autores principales:	Seegobin K, Alhaj Moustafa M, Jiang L, Tun HW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	richter transformation rt chronic lymphocytic leukemia cll double hit lymphoma ibrutinib maintenance Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/8c325bbea53e476ca0f7d42ff524874f
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spelling	oai:doaj.org-article:8c325bbea53e476ca0f7d42ff524874f2021-12-02T17:25:46ZSuccessful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission1179-9889https://doaj.org/article/8c325bbea53e476ca0f7d42ff524874f2021-09-01T00:00:00Zhttps://www.dovepress.com/successful-non-transplant-treatment-of-double-hit-richter-transformati-peer-reviewed-fulltext-article-BLCTThttps://doaj.org/toc/1179-9889Karan Seegobin,1 Muhamad Alhaj Moustafa,1 Liuyan Jiang,2 Han W Tun1 1Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USA; 2Department of Pathology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USACorrespondence: Karan SeegobinDepartment of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USAEmail seegobin.karan@mayo.eduAbstract: Richter transformation (RT) is defined as the transformation of chronic lymphocytic leukemia (CLL) to a high-grade B cell lymphoma. It usually carries a dismal prognosis and represents an unmet need for novel therapeutic interventions. We report a case of an 80-year-old male who developed double-hit (DH) RT with translocations of MYC and BCL6 after 5 years of watchful waiting for standard-risk CLL. He was treated with induction therapy consisting of 4 cycles of anthracycline-based chemoimmunotherapy (CIT) and 2 cycles of platinum-based CIT with intrathecal methotrexate for CNS prophylaxis followed by continuous maintenance therapy with ibrutinib. He achieved complete remission after the induction therapy. At the time of writing, four and a half years after the diagnosis with DH-RT, he remains in complete remission without evidence of RT or CLL. The novel therapeutic approach used in successful treatment of this patient should be further explored.Keywords: Richter transformation, RT, chronic lymphocytic leukemia, CLL, double hit lymphoma, ibrutinib maintenanceSeegobin KAlhaj Moustafa MJiang LTun HWDove Medical Pressarticlerichter transformationrtchronic lymphocytic leukemiaclldouble hit lymphomaibrutinib maintenanceDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol Volume 11, Pp 67-72 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	richter transformation rt chronic lymphocytic leukemia cll double hit lymphoma ibrutinib maintenance Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	richter transformation rt chronic lymphocytic leukemia cll double hit lymphoma ibrutinib maintenance Diseases of the blood and blood-forming organs RC633-647.5 Seegobin K Alhaj Moustafa M Jiang L Tun HW Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
description	Karan Seegobin,1 Muhamad Alhaj Moustafa,1 Liuyan Jiang,2 Han W Tun1 1Department of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USA; 2Department of Pathology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USACorrespondence: Karan SeegobinDepartment of Hematology and Medical Oncology, Mayo Clinic Hospital, Jacksonville City, FL, 32224, USAEmail seegobin.karan@mayo.eduAbstract: Richter transformation (RT) is defined as the transformation of chronic lymphocytic leukemia (CLL) to a high-grade B cell lymphoma. It usually carries a dismal prognosis and represents an unmet need for novel therapeutic interventions. We report a case of an 80-year-old male who developed double-hit (DH) RT with translocations of MYC and BCL6 after 5 years of watchful waiting for standard-risk CLL. He was treated with induction therapy consisting of 4 cycles of anthracycline-based chemoimmunotherapy (CIT) and 2 cycles of platinum-based CIT with intrathecal methotrexate for CNS prophylaxis followed by continuous maintenance therapy with ibrutinib. He achieved complete remission after the induction therapy. At the time of writing, four and a half years after the diagnosis with DH-RT, he remains in complete remission without evidence of RT or CLL. The novel therapeutic approach used in successful treatment of this patient should be further explored.Keywords: Richter transformation, RT, chronic lymphocytic leukemia, CLL, double hit lymphoma, ibrutinib maintenance
format	article
author	Seegobin K Alhaj Moustafa M Jiang L Tun HW
author_facet	Seegobin K Alhaj Moustafa M Jiang L Tun HW
author_sort	Seegobin K
title	Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
title_short	Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
title_full	Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
title_fullStr	Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
title_full_unstemmed	Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission
title_sort	successful non-transplant treatment of double hit richter transformation with long-term remission
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8c325bbea53e476ca0f7d42ff524874f
work_keys_str_mv	AT seegobink successfulnontransplanttreatmentofdoublehitrichtertransformationwithlongtermremission AT alhajmoustafam successfulnontransplanttreatmentofdoublehitrichtertransformationwithlongtermremission AT jiangl successfulnontransplanttreatmentofdoublehitrichtertransformationwithlongtermremission AT tunhw successfulnontransplanttreatmentofdoublehitrichtertransformationwithlongtermremission
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Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission

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