Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction

Abstract Cosmos caudatus (C. caudatus) is a medicinal plant that is high in bioactive compounds such as phenolics. In this study, an ultrasound extraction method was used to optimise the extraction of bioactive compounds from C. caudatus leaves. Response surface methodology (RSM) based on a Box-Behn...

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Autores principales:	Norliza Abdul Latiff, Pei Ying Ong, Siti Nor Azlina Abd Rashid, Luqman Chuah Abdullah, Nor Amaiza Mohd Amin, Noor Akhmazillah Mohd Fauzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c34034572f24a289ac0f2890bd3d190
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spelling	oai:doaj.org-article:8c34034572f24a289ac0f2890bd3d1902021-12-02T19:02:23ZEnhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction10.1038/s41598-021-96623-x2045-2322https://doaj.org/article/8c34034572f24a289ac0f2890bd3d1902021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96623-xhttps://doaj.org/toc/2045-2322Abstract Cosmos caudatus (C. caudatus) is a medicinal plant that is high in bioactive compounds such as phenolics. In this study, an ultrasound extraction method was used to optimise the extraction of bioactive compounds from C. caudatus leaves. Response surface methodology (RSM) based on a Box-Behnken design (BBD) was applied to obtain the optimum extraction parameters which is solid–liquid ratio (10–30 g/mL), particle size (180–850 µm) and extraction time (20–30 min) for maximal quercitrin and total phenolic content (TPC) yields. Analysis of antimicrobial activity was performed against two human pathogenic microbes: Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) by the agar well diffusion method. The optimal ultrasonic extraction condition was as follow: solvent-liquid ratio of 1:28 (g/mL), particle size of 485 µm, and duration of 30 min, respectively. Remarkably, extraction using ultrasonic method had recovered more bioactive content and antioxidant activity than the Soxhlet method. The extract also exhibited good antimicrobial activities. Due to the above findings, the ultrasonic extraction was found to be suitable to improve recovery extraction of quercitrin and TPC from C. caudatus leaves. It also opens the possibility that the plant extract can be used for functional food and antimicrobial agents in various applications.Norliza Abdul LatiffPei Ying OngSiti Nor Azlina Abd RashidLuqman Chuah AbdullahNor Amaiza Mohd AminNoor Akhmazillah Mohd FauziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Norliza Abdul Latiff Pei Ying Ong Siti Nor Azlina Abd Rashid Luqman Chuah Abdullah Nor Amaiza Mohd Amin Noor Akhmazillah Mohd Fauzi Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
description	Abstract Cosmos caudatus (C. caudatus) is a medicinal plant that is high in bioactive compounds such as phenolics. In this study, an ultrasound extraction method was used to optimise the extraction of bioactive compounds from C. caudatus leaves. Response surface methodology (RSM) based on a Box-Behnken design (BBD) was applied to obtain the optimum extraction parameters which is solid–liquid ratio (10–30 g/mL), particle size (180–850 µm) and extraction time (20–30 min) for maximal quercitrin and total phenolic content (TPC) yields. Analysis of antimicrobial activity was performed against two human pathogenic microbes: Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) by the agar well diffusion method. The optimal ultrasonic extraction condition was as follow: solvent-liquid ratio of 1:28 (g/mL), particle size of 485 µm, and duration of 30 min, respectively. Remarkably, extraction using ultrasonic method had recovered more bioactive content and antioxidant activity than the Soxhlet method. The extract also exhibited good antimicrobial activities. Due to the above findings, the ultrasonic extraction was found to be suitable to improve recovery extraction of quercitrin and TPC from C. caudatus leaves. It also opens the possibility that the plant extract can be used for functional food and antimicrobial agents in various applications.
format	article
author	Norliza Abdul Latiff Pei Ying Ong Siti Nor Azlina Abd Rashid Luqman Chuah Abdullah Nor Amaiza Mohd Amin Noor Akhmazillah Mohd Fauzi
author_facet	Norliza Abdul Latiff Pei Ying Ong Siti Nor Azlina Abd Rashid Luqman Chuah Abdullah Nor Amaiza Mohd Amin Noor Akhmazillah Mohd Fauzi
author_sort	Norliza Abdul Latiff
title	Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
title_short	Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
title_full	Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
title_fullStr	Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
title_full_unstemmed	Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction
title_sort	enhancing recovery of bioactive compounds from cosmos caudatus leaves via ultrasonic extraction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c34034572f24a289ac0f2890bd3d190
work_keys_str_mv	AT norlizaabdullatiff enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction AT peiyingong enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction AT sitinorazlinaabdrashid enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction AT luqmanchuahabdullah enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction AT noramaizamohdamin enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction AT noorakhmazillahmohdfauzi enhancingrecoveryofbioactivecompoundsfromcosmoscaudatusleavesviaultrasonicextraction
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Enhancing recovery of bioactive compounds from Cosmos caudatus leaves via ultrasonic extraction

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