ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS

Infective endocarditis (IE) is a septic inflammation of endocardium, which generally involves the lining of the heart chambers and heart valves. The development of IE depends in many respects on how properly and efficiently the immune system responds to the occurrence of an infection. Innate immunit...

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Autores principales:	A. V. Ponasenko, A. G. Kutikhin, M. V. Khutornaya, A. E. Yuzhalin, N. V. Rutkovskaya, A. S. Golovkin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	infective endocarditis gene polymorphisms innate immunity trem-1 inflammatory response infectious immunity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8c38c0807db84873a74271845265d79e
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spelling	oai:doaj.org-article:8c38c0807db84873a74271845265d79e2021-11-22T07:09:47ZASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS2220-76192313-739810.15789/2220-7619-2015-4-331-338https://doaj.org/article/8c38c0807db84873a74271845265d79e2016-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/350https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Infective endocarditis (IE) is a septic inflammation of endocardium, which generally involves the lining of the heart chambers and heart valves. The development of IE depends in many respects on how properly and efficiently the immune system responds to the occurrence of an infection. Innate immunity, which carries out the response to a transient bacteremia, is genetically determined in a large extent. Pattern recognition receptors, which identify pathogenand danger-associated molecular patterns, are the main effectors of innate immune response; one of these receptors is triggering receptor expressed on myeloid cells-1 (TREM-1). We hypothesized that inherited variation in TREM-1 gene may affect individual susceptibility to IE. The distribution of genotypes and alleles of rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, and rs2234237 gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that rs1817537 polymorphism was associated with decreased IE risk (OR = 0.60; 95%CI = 0.37–0.99; р = 0.046, dominant model); however, this was not significant after an adjustment for multiple comparisons. Therefore, we observed no statistically significant association between the investigated polymorphisms within TREM-1 gene and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.A. V. PonasenkoA. G. KutikhinM. V. KhutornayaA. E. YuzhalinN. V. RutkovskayaA. S. GolovkinSankt-Peterburg : NIIÈM imeni Pasteraarticleinfective endocarditisgene polymorphismsinnate immunitytrem-1inflammatory responseinfectious immunityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 5, Iss 4, Pp 331-338 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	infective endocarditis gene polymorphisms innate immunity trem-1 inflammatory response infectious immunity Infectious and parasitic diseases RC109-216
spellingShingle	infective endocarditis gene polymorphisms innate immunity trem-1 inflammatory response infectious immunity Infectious and parasitic diseases RC109-216 A. V. Ponasenko A. G. Kutikhin M. V. Khutornaya A. E. Yuzhalin N. V. Rutkovskaya A. S. Golovkin ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
description	Infective endocarditis (IE) is a septic inflammation of endocardium, which generally involves the lining of the heart chambers and heart valves. The development of IE depends in many respects on how properly and efficiently the immune system responds to the occurrence of an infection. Innate immunity, which carries out the response to a transient bacteremia, is genetically determined in a large extent. Pattern recognition receptors, which identify pathogenand danger-associated molecular patterns, are the main effectors of innate immune response; one of these receptors is triggering receptor expressed on myeloid cells-1 (TREM-1). We hypothesized that inherited variation in TREM-1 gene may affect individual susceptibility to IE. The distribution of genotypes and alleles of rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, and rs2234237 gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that rs1817537 polymorphism was associated with decreased IE risk (OR = 0.60; 95%CI = 0.37–0.99; р = 0.046, dominant model); however, this was not significant after an adjustment for multiple comparisons. Therefore, we observed no statistically significant association between the investigated polymorphisms within TREM-1 gene and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.
format	article
author	A. V. Ponasenko A. G. Kutikhin M. V. Khutornaya A. E. Yuzhalin N. V. Rutkovskaya A. S. Golovkin
author_facet	A. V. Ponasenko A. G. Kutikhin M. V. Khutornaya A. E. Yuzhalin N. V. Rutkovskaya A. S. Golovkin
author_sort	A. V. Ponasenko
title	ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
title_short	ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
title_full	ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
title_fullStr	ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
title_full_unstemmed	ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS
title_sort	association of trem-1 gene polymorphisms with infective endocarditis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/8c38c0807db84873a74271845265d79e
work_keys_str_mv	AT avponasenko associationoftrem1genepolymorphismswithinfectiveendocarditis AT agkutikhin associationoftrem1genepolymorphismswithinfectiveendocarditis AT mvkhutornaya associationoftrem1genepolymorphismswithinfectiveendocarditis AT aeyuzhalin associationoftrem1genepolymorphismswithinfectiveendocarditis AT nvrutkovskaya associationoftrem1genepolymorphismswithinfectiveendocarditis AT asgolovkin associationoftrem1genepolymorphismswithinfectiveendocarditis
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ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS

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