Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress

Abstract Genomic instability drives tumorigenesis and DNA repair defects are associated with elevated cancer. Metabolic alterations are also observed during tumorigenesis, although a causal relationship between these has not been clearly established. Xeroderma pigmentosum (XP) is a DNA repair diseas...

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Autores principales: Mateus P. Mori, Rute A. P. Costa, Daniela T. Soltys, Thiago de S. Freire, Franco A. Rossato, Ignácio Amigo, Alicia J. Kowaltowski, Aníbal E. Vercesi, Nadja C. de Souza-Pinto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8c3abd91e76c4e26a1355a84576051ac
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