Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.
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Nature Portfolio
2021
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oai:doaj.org-article:8c3b78ae6a934bf382bdde9f4a4a758d2021-12-02T14:54:28ZCapillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice10.1038/s41467-021-25590-82041-1723https://doaj.org/article/8c3b78ae6a934bf382bdde9f4a4a758d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25590-8https://doaj.org/toc/2041-1723Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.Kanchan BishtKenneth A. OkojieKaushik SharmaDennis H. LentferinkYu-Yo SunHong-Ru ChenJoseph O. UweruSaipranusha AmancherlaZainab CalcuttawalaAntony Brayan Campos-SalazarBruce CorlissLara JabbourJordan BenderothBria FriestadWilliam A. MillsBrant E. IsaksonMarie-Ève TremblayChia-Yi KuanUkpong B. EyoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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| topic |
Science Q |
| spellingShingle |
Science Q Kanchan Bisht Kenneth A. Okojie Kaushik Sharma Dennis H. Lentferink Yu-Yo Sun Hong-Ru Chen Joseph O. Uweru Saipranusha Amancherla Zainab Calcuttawala Antony Brayan Campos-Salazar Bruce Corliss Lara Jabbour Jordan Benderoth Bria Friestad William A. Mills Brant E. Isakson Marie-Ève Tremblay Chia-Yi Kuan Ukpong B. Eyo Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| description |
Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling. |
| format |
article |
| author |
Kanchan Bisht Kenneth A. Okojie Kaushik Sharma Dennis H. Lentferink Yu-Yo Sun Hong-Ru Chen Joseph O. Uweru Saipranusha Amancherla Zainab Calcuttawala Antony Brayan Campos-Salazar Bruce Corliss Lara Jabbour Jordan Benderoth Bria Friestad William A. Mills Brant E. Isakson Marie-Ève Tremblay Chia-Yi Kuan Ukpong B. Eyo |
| author_facet |
Kanchan Bisht Kenneth A. Okojie Kaushik Sharma Dennis H. Lentferink Yu-Yo Sun Hong-Ru Chen Joseph O. Uweru Saipranusha Amancherla Zainab Calcuttawala Antony Brayan Campos-Salazar Bruce Corliss Lara Jabbour Jordan Benderoth Bria Friestad William A. Mills Brant E. Isakson Marie-Ève Tremblay Chia-Yi Kuan Ukpong B. Eyo |
| author_sort |
Kanchan Bisht |
| title |
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| title_short |
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| title_full |
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| title_fullStr |
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| title_full_unstemmed |
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice |
| title_sort |
capillary-associated microglia regulate vascular structure and function through panx1-p2ry12 coupling in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8c3b78ae6a934bf382bdde9f4a4a758d |
| work_keys_str_mv |
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