Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder

Nuray Türksoy,1 Rabia Bilici,2 Altan Yalçiner,3 Y Özay Özdemir,2 Ibrahim Örnek,4 Ali Evren Tufan,5 Ayşe Kara6 1Simurg Psychiatry and Psychotherapy Center, Istanbul, 2Erenköy State Hospital for Psychiatric and Neurological Diseases, Istanbul,...

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Autores principales: Türksoy N, Bilici R, Yalçıner A, Özdemir YÖ, Örnek I, Tufan AE, Kara A
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Publicado: Dove Medical Press 2014
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spelling oai:doaj.org-article:8c3c2e66833940b0b02b6a2323bccede2021-12-02T02:18:43ZVitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder1178-2021https://doaj.org/article/8c3c2e66833940b0b02b6a2323bccede2014-09-01T00:00:00Zhttp://www.dovepress.com/vitamin-b12-folate-and-homocysteine-levels-in-patients-with-obsessiven-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Nuray Türksoy,1 Rabia Bilici,2 Altan Yalçiner,3 Y Özay Özdemir,2 Ibrahim Örnek,4 Ali Evren Tufan,5 Ayşe Kara6 1Simurg Psychiatry and Psychotherapy Center, Istanbul, 2Erenköy State Hospital for Psychiatric and Neurological Diseases, Istanbul, 3Düzen Laboratories, Istanbul, 4Florence Nightingale Hospital, Istanbul, 5Department of Child and Adolescent Psychiatry, Abant Izzet Baysal University, Bolu, 6Bakırköy State Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey Abstract: It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders – especially in obsessive–compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale–Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale–Brown compulsion and Yale–Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels. Keywords: obsessive–compulsive disorder, vitamin B12, folate, homocysteine, obsession, compulsionTürksoy NBilici RYalçıner AÖzdemir YÖÖrnek ITufan AEKara ADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1671-1675 (2014)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Türksoy N
Bilici R
Yalçıner A
Özdemir YÖ
Örnek I
Tufan AE
Kara A
Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
description Nuray Türksoy,1 Rabia Bilici,2 Altan Yalçiner,3 Y Özay Özdemir,2 Ibrahim Örnek,4 Ali Evren Tufan,5 Ayşe Kara6 1Simurg Psychiatry and Psychotherapy Center, Istanbul, 2Erenköy State Hospital for Psychiatric and Neurological Diseases, Istanbul, 3Düzen Laboratories, Istanbul, 4Florence Nightingale Hospital, Istanbul, 5Department of Child and Adolescent Psychiatry, Abant Izzet Baysal University, Bolu, 6Bakırköy State Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey Abstract: It is known that elevated serum homocysteine, decreased folate, and low vitamin B12 serum levels are associated with poor cognitive function, cognitive decline, and dementia. Current literature shows that some psychiatric disorders, mainly affective and psychotic ones, can be related to the levels of vitamin B12, folate, and homocysteine. These results can be explained by the importance of vitamin B12, folate, and homocysteine in carbon transfer metabolism (methylation), which is required for the production of serotonin as well as for other monoamine neurotransmitters and catecholamines. Earlier studies focused on the relationship between folate deficiency, hyperhomocysteinemia, and depressive disorders. Although depressive and anxiety disorders show a common comorbidity pattern, there are few studies addressing the effect of impaired one-carbon metabolism in anxiety disorders – especially in obsessive–compulsive disorder (OCD). This study aimed to measure the levels of vitamin B12, folate, and homocysteine specifically in order to see if eventual alterations have an etiopathogenetic significance on patients with OCD. Serum vitamin B12, folate, and homocysteine concentrations were measured in 35 patients with OCD and 22 controls. In addition, the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Yale–Brown Obsessive Compulsive Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety were conducted for each patient. It was found that vitamin B12 levels were decreased and homocysteine levels were increased in some OCD patients. Homocysteine levels were positively correlated with Yale–Brown compulsion and Yale–Brown total scores. In conclusion, findings of this study suggest that some OCD patients might have vitamin B12 deficiency and higher homocysteine levels. Keywords: obsessive–compulsive disorder, vitamin B12, folate, homocysteine, obsession, compulsion
format article
author Türksoy N
Bilici R
Yalçıner A
Özdemir YÖ
Örnek I
Tufan AE
Kara A
author_facet Türksoy N
Bilici R
Yalçıner A
Özdemir YÖ
Örnek I
Tufan AE
Kara A
author_sort Türksoy N
title Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
title_short Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
title_full Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
title_fullStr Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
title_full_unstemmed Vitamin B12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
title_sort vitamin b12, folate, and homocysteine levels in patients with obsessive–compulsive disorder
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/8c3c2e66833940b0b02b6a2323bccede
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