Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners

Objective: Both exercise and cold exposure cause physiological stress and they often occur in combination. However, the effects of exercise during severe cold on variation in bone metabolism in humans have remained elusive. The aim of this study was to investigate the variations in circulating bone...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shuai Mu, Yang Xia, Qijun Wu, Chao Ji, Huixu Dai, Ming Zhang, Jiao Jiao, Feng Shi, Shengye Liu, Guangbin Wang, Tao Shen, Ye Tian, Liqing Yang, Qin Fu, Yuhong Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bone (re)modeling markers parathyroid hormone (PTH) bone mineral density exercise cold exposure Physiology QP1-981
Acceso en línea:	https://doaj.org/article/8c3d325c1d374d0a9e9b9d749fc8b016
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c3d325c1d374d0a9e9b9d749fc8b016
record_format	dspace
spelling	oai:doaj.org-article:8c3d325c1d374d0a9e9b9d749fc8b0162021-12-01T07:47:23ZResponse of Bone Metabolism Markers to Ice Swimming in Regular Practitioners1664-042X10.3389/fphys.2021.731523https://doaj.org/article/8c3d325c1d374d0a9e9b9d749fc8b0162021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.731523/fullhttps://doaj.org/toc/1664-042XObjective: Both exercise and cold exposure cause physiological stress and they often occur in combination. However, the effects of exercise during severe cold on variation in bone metabolism in humans have remained elusive. The aim of this study was to investigate the variations in circulating bone metabolism markers after ice swimming (IS).Methods: Eighty-seven women and men aged 42–84 years old were recruited to perform regular IS activities. Serum parathyroid hormone (PTH), total calcium (Ca2+), total phosphorus (Pi), total magnesium (Mg2+), N-terminal osteocalcin (N-MID), total propeptide of procollagen 1 (TPINP), and C-terminal telopeptide of type 1 collagen (β-CTX) were measured 30 min before and 30 min after IS. Bone mineral content (BMC) and bone mineral density (BMD) were assessed at lumbar spine 1–4 (L1–L4) and femoral neck (FN). The IS habits were obtained from questionnaires and the 10-year probability of osteoporotic fracture was calculated using the FRAX® tool with and without a BMD value of the FN.Results: There were significant increases in PTH (median, 40.120–51.540 pg/mL), Ca2+ (median, 2.330–2.400 mmol/L), and Pi (median, 1.100–1.340 mmol/L) and significant decreases in TPINP (median, 38.190–36.610 ng/mL) and β-CTX (median, 0.185–0.171 ng/mL), while there was a trend for increased serum Mg2+ (P = 0.058) but no significant change in N-MID (P = 0.933) after IS in all subjects. The increases in the proportions of cases of hyperparathyroidemia, hypercalcemia, and hyperphosphatemia in those performing IS were statistically significant. The baseline levels and the changes of bone metabolism markers had associations with osteoporosis and bone status, but these may be age and sex dependent. Finally, there were significant correlations among the bone metabolism markers.Conclusion: IS caused significant alterations in bone metabolic markers, specifically, increases in PTH, Ca2+ and Pi should raise concerns about potential cardiovascular health risks in severe cold exercise. Additionally, a divergence between PTH elevation and a decline in bone turnover, which shown a special change of bone metabolism after IS and may suggest potential therapeutic implications of cold exercise in PTH and bone metabolic disorders.Shuai MuYang XiaQijun WuChao JiHuixu DaiMing ZhangJiao JiaoFeng ShiShengye LiuGuangbin WangTao ShenYe TianLiqing YangQin FuYuhong ZhaoFrontiers Media S.A.articlebone (re)modeling markersparathyroid hormone (PTH)bone mineral densityexercisecold exposurePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone (re)modeling markers parathyroid hormone (PTH) bone mineral density exercise cold exposure Physiology QP1-981
spellingShingle	bone (re)modeling markers parathyroid hormone (PTH) bone mineral density exercise cold exposure Physiology QP1-981 Shuai Mu Yang Xia Qijun Wu Chao Ji Huixu Dai Ming Zhang Jiao Jiao Feng Shi Shengye Liu Guangbin Wang Tao Shen Ye Tian Liqing Yang Qin Fu Yuhong Zhao Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
description	Objective: Both exercise and cold exposure cause physiological stress and they often occur in combination. However, the effects of exercise during severe cold on variation in bone metabolism in humans have remained elusive. The aim of this study was to investigate the variations in circulating bone metabolism markers after ice swimming (IS).Methods: Eighty-seven women and men aged 42–84 years old were recruited to perform regular IS activities. Serum parathyroid hormone (PTH), total calcium (Ca2+), total phosphorus (Pi), total magnesium (Mg2+), N-terminal osteocalcin (N-MID), total propeptide of procollagen 1 (TPINP), and C-terminal telopeptide of type 1 collagen (β-CTX) were measured 30 min before and 30 min after IS. Bone mineral content (BMC) and bone mineral density (BMD) were assessed at lumbar spine 1–4 (L1–L4) and femoral neck (FN). The IS habits were obtained from questionnaires and the 10-year probability of osteoporotic fracture was calculated using the FRAX® tool with and without a BMD value of the FN.Results: There were significant increases in PTH (median, 40.120–51.540 pg/mL), Ca2+ (median, 2.330–2.400 mmol/L), and Pi (median, 1.100–1.340 mmol/L) and significant decreases in TPINP (median, 38.190–36.610 ng/mL) and β-CTX (median, 0.185–0.171 ng/mL), while there was a trend for increased serum Mg2+ (P = 0.058) but no significant change in N-MID (P = 0.933) after IS in all subjects. The increases in the proportions of cases of hyperparathyroidemia, hypercalcemia, and hyperphosphatemia in those performing IS were statistically significant. The baseline levels and the changes of bone metabolism markers had associations with osteoporosis and bone status, but these may be age and sex dependent. Finally, there were significant correlations among the bone metabolism markers.Conclusion: IS caused significant alterations in bone metabolic markers, specifically, increases in PTH, Ca2+ and Pi should raise concerns about potential cardiovascular health risks in severe cold exercise. Additionally, a divergence between PTH elevation and a decline in bone turnover, which shown a special change of bone metabolism after IS and may suggest potential therapeutic implications of cold exercise in PTH and bone metabolic disorders.
format	article
author	Shuai Mu Yang Xia Qijun Wu Chao Ji Huixu Dai Ming Zhang Jiao Jiao Feng Shi Shengye Liu Guangbin Wang Tao Shen Ye Tian Liqing Yang Qin Fu Yuhong Zhao
author_facet	Shuai Mu Yang Xia Qijun Wu Chao Ji Huixu Dai Ming Zhang Jiao Jiao Feng Shi Shengye Liu Guangbin Wang Tao Shen Ye Tian Liqing Yang Qin Fu Yuhong Zhao
author_sort	Shuai Mu
title	Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
title_short	Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
title_full	Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
title_fullStr	Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
title_full_unstemmed	Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners
title_sort	response of bone metabolism markers to ice swimming in regular practitioners
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8c3d325c1d374d0a9e9b9d749fc8b016
work_keys_str_mv	AT shuaimu responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT yangxia responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT qijunwu responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT chaoji responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT huixudai responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT mingzhang responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT jiaojiao responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT fengshi responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT shengyeliu responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT guangbinwang responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT taoshen responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT yetian responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT liqingyang responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT qinfu responseofbonemetabolismmarkerstoiceswimminginregularpractitioners AT yuhongzhao responseofbonemetabolismmarkerstoiceswimminginregularpractitioners
_version_	1718405425345331200

Response of Bone Metabolism Markers to Ice Swimming in Regular Practitioners

Ejemplares similares