Age-related changes in corneal thickness and endothelial characteristics

Saulius Galgauskas, Dovilė Norvydaitė, Dalia Krasauskaitė, Simona Stech, Rimvydas Stanislovas A&scaron;oklisVilnius University Faculty of Medicine, ENT and Eye Diseases Clinic, Vilnius University Hospital Santariskiu Clinic, Center of Eye Diseases, Vilnius, LithuaniaPurpose: To determine the inf...

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Autores principales:	Galgauskas S, Norvydaitė D, Krasauskaitė D, Stech S, A&scaron;oklis RS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	cornea endothelium central corneal thickness age-related changes. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8c3dc492ed924736b126c0cafb7b0e22
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spelling	oai:doaj.org-article:8c3dc492ed924736b126c0cafb7b0e222021-12-02T03:50:52ZAge-related changes in corneal thickness and endothelial characteristics1178-1998https://doaj.org/article/8c3dc492ed924736b126c0cafb7b0e222013-10-01T00:00:00Zhttps://www.dovepress.com/age-related-changes-in-corneal-thickness-and-endothelial-characteristi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Saulius Galgauskas, Dovilė Norvydaitė, Dalia Krasauskaitė, Simona Stech, Rimvydas Stanislovas A&scaron;oklisVilnius University Faculty of Medicine, ENT and Eye Diseases Clinic, Vilnius University Hospital Santariskiu Clinic, Center of Eye Diseases, Vilnius, LithuaniaPurpose: To determine the influence of age on central corneal thickness (CCT), endothelial cell density (ECD), average cell size, coefficient of variation in cell size, and percentage of regular hexagonal cells; and to estimate the average ECD and CCT in seven age groups.Materials and methods: After obtaining informed consent, 211 Caucasian patients (358 eyes) were examined using a noncontact specular microscope at the Center of Eye Diseases in Vilnius University Hospital Santariskiu Clinic. The main corneal parameters were: ECD, average cell size, coefficient of variation in cell size, percentage of regular hexagonal cells, and CCT. Subjects (20–89 years) were stratified by age into seven groups. Correlations between CCT, endothelial parameters (ECD, percentage of regular hexagonal cells, average, coefficient of variation), and age were found. Student’s t-test and Pearson's correlation coefficient (r) values were calculated.Results: A total of 114 (54.03%) women and 97 (45.97%) men participated in the study. Average ECD (cell/mm2) ranged from 2,931 (±371) in 20–29 year olds to 2,222 (±182) in 80–89 year olds; CCT (µm) ranged from 563 (±44) in 20–29 year olds to 540 (±35) in 80–89 year olds. A strong inverse correlation was observed between age and corneal ECD (r=-0.650, P<0.01) and a weak inverse correlation was observed between age and CCT (r=-0.156, P<0.01). ECD and CCT correlated directly (r=0.232, P<0.01). The average size of corneal endothelial cells directly correlated with age (r=0.586, P<0.01). There was no correlation between age and the coefficient of variation in cell size nor the percentage of regular hexagonal cells (P>0.05).Conclusion: Young people have higher ECD. CCT also decreases, but its dependence on age is weaker. A lower cell density indicates a thinner cornea. The variation in cell size and percentage of regular hexagonal cells are not dependent on age.Keywords: cornea, endothelium, age-related changesGalgauskas SNorvydaitė DKrasauskaitė DStech SA&scaron;oklis RSDove Medical Pressarticlecorneaendotheliumcentral corneal thicknessage-related changes.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1445-1450 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea endothelium central corneal thickness age-related changes. Geriatrics RC952-954.6
spellingShingle	cornea endothelium central corneal thickness age-related changes. Geriatrics RC952-954.6 Galgauskas S Norvydaitė D Krasauskaitė D Stech S A&scaron;oklis RS Age-related changes in corneal thickness and endothelial characteristics
description	Saulius Galgauskas, Dovilė Norvydaitė, Dalia Krasauskaitė, Simona Stech, Rimvydas Stanislovas A&scaron;oklisVilnius University Faculty of Medicine, ENT and Eye Diseases Clinic, Vilnius University Hospital Santariskiu Clinic, Center of Eye Diseases, Vilnius, LithuaniaPurpose: To determine the influence of age on central corneal thickness (CCT), endothelial cell density (ECD), average cell size, coefficient of variation in cell size, and percentage of regular hexagonal cells; and to estimate the average ECD and CCT in seven age groups.Materials and methods: After obtaining informed consent, 211 Caucasian patients (358 eyes) were examined using a noncontact specular microscope at the Center of Eye Diseases in Vilnius University Hospital Santariskiu Clinic. The main corneal parameters were: ECD, average cell size, coefficient of variation in cell size, percentage of regular hexagonal cells, and CCT. Subjects (20–89 years) were stratified by age into seven groups. Correlations between CCT, endothelial parameters (ECD, percentage of regular hexagonal cells, average, coefficient of variation), and age were found. Student’s t-test and Pearson's correlation coefficient (r) values were calculated.Results: A total of 114 (54.03%) women and 97 (45.97%) men participated in the study. Average ECD (cell/mm2) ranged from 2,931 (±371) in 20–29 year olds to 2,222 (±182) in 80–89 year olds; CCT (µm) ranged from 563 (±44) in 20–29 year olds to 540 (±35) in 80–89 year olds. A strong inverse correlation was observed between age and corneal ECD (r=-0.650, P<0.01) and a weak inverse correlation was observed between age and CCT (r=-0.156, P<0.01). ECD and CCT correlated directly (r=0.232, P<0.01). The average size of corneal endothelial cells directly correlated with age (r=0.586, P<0.01). There was no correlation between age and the coefficient of variation in cell size nor the percentage of regular hexagonal cells (P>0.05).Conclusion: Young people have higher ECD. CCT also decreases, but its dependence on age is weaker. A lower cell density indicates a thinner cornea. The variation in cell size and percentage of regular hexagonal cells are not dependent on age.Keywords: cornea, endothelium, age-related changes
format	article
author	Galgauskas S Norvydaitė D Krasauskaitė D Stech S A&scaron;oklis RS
author_facet	Galgauskas S Norvydaitė D Krasauskaitė D Stech S A&scaron;oklis RS
author_sort	Galgauskas S
title	Age-related changes in corneal thickness and endothelial characteristics
title_short	Age-related changes in corneal thickness and endothelial characteristics
title_full	Age-related changes in corneal thickness and endothelial characteristics
title_fullStr	Age-related changes in corneal thickness and endothelial characteristics
title_full_unstemmed	Age-related changes in corneal thickness and endothelial characteristics
title_sort	age-related changes in corneal thickness and endothelial characteristics
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/8c3dc492ed924736b126c0cafb7b0e22
work_keys_str_mv	AT galgauskass agerelatedchangesincornealthicknessandendothelialcharacteristics AT norvydaited agerelatedchangesincornealthicknessandendothelialcharacteristics AT krasauskaited agerelatedchangesincornealthicknessandendothelialcharacteristics AT stechs agerelatedchangesincornealthicknessandendothelialcharacteristics AT ascaronoklisrs agerelatedchangesincornealthicknessandendothelialcharacteristics
_version_	1718401606161006592

Age-related changes in corneal thickness and endothelial characteristics

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