Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

ABSTRACT Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), we identified monoclonal antibody (MAb) 2D3, which...

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Autores principales: Abimbola O. Kolawole, Hong Q. Smith, Sophia A. Svoboda, Madeline S. Lewis, Michael B. Sherman, Gillian C. Lynch, B. Montgomery Pettitt, Thomas J. Smith, Christiane E. Wobus
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
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Acceso en línea:https://doaj.org/article/8c3e915739ee40cdb50d1aac4ea2b75c
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