The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population.
Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been associated...
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2008
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oai:doaj.org-article:8c43057a41e243b4b0be2318d447c8632021-11-25T06:11:11ZThe CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population.1932-620310.1371/journal.pone.0002953https://doaj.org/article/8c43057a41e243b4b0be2318d447c8632008-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18698425/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), a complex metabolic disorder with increased risk of cardiovascular disease. Moreover, the CAPN10 gene has been associated with the presence of metabolic syndrome (MS) in T2DM and in polycystic ovary syndrome (PCOS). In this work, we have analysed whether the polymorphisms UCSNP44, -43, -19 and -63 are related to several cardiovascular risk factors in the context of MS. Molecular analysis of CAPN10 gene was performed in 899 individuals randomly chosen from a cross-sectional population-based epidemiological survey. We have found that CAPN10 gene in our population is mainly associated with two indicators of the presence of insulin resistance: glucose levels two hours after a 75-g oral glucose tolerance test (OGTT) and HOMA values, although cholesterol levels and blood pressure values are also influenced by CAPN10 variants. In addition, the 1221/1121 haplogenotype is under-represented in individuals that fulfil the International Diabetes Federation (IDF) diagnostic criteria for MS. Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population.María E SáezJosé L González-SánchezReposo Ramírez-LorcaMaría T Martínez-LarradCarina ZabenaAlejandro GonzálezFrancisco J MorónAgustín RuizManuel Serrano-RíosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 8, p e2953 (2008) |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q María E Sáez José L González-Sánchez Reposo Ramírez-Lorca María T Martínez-Larrad Carina Zabena Alejandro González Francisco J Morón Agustín Ruiz Manuel Serrano-Ríos The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| description |
Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), a complex metabolic disorder with increased risk of cardiovascular disease. Moreover, the CAPN10 gene has been associated with the presence of metabolic syndrome (MS) in T2DM and in polycystic ovary syndrome (PCOS). In this work, we have analysed whether the polymorphisms UCSNP44, -43, -19 and -63 are related to several cardiovascular risk factors in the context of MS. Molecular analysis of CAPN10 gene was performed in 899 individuals randomly chosen from a cross-sectional population-based epidemiological survey. We have found that CAPN10 gene in our population is mainly associated with two indicators of the presence of insulin resistance: glucose levels two hours after a 75-g oral glucose tolerance test (OGTT) and HOMA values, although cholesterol levels and blood pressure values are also influenced by CAPN10 variants. In addition, the 1221/1121 haplogenotype is under-represented in individuals that fulfil the International Diabetes Federation (IDF) diagnostic criteria for MS. Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| format |
article |
| author |
María E Sáez José L González-Sánchez Reposo Ramírez-Lorca María T Martínez-Larrad Carina Zabena Alejandro González Francisco J Morón Agustín Ruiz Manuel Serrano-Ríos |
| author_facet |
María E Sáez José L González-Sánchez Reposo Ramírez-Lorca María T Martínez-Larrad Carina Zabena Alejandro González Francisco J Morón Agustín Ruiz Manuel Serrano-Ríos |
| author_sort |
María E Sáez |
| title |
The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| title_short |
The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| title_full |
The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| title_fullStr |
The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| title_full_unstemmed |
The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. |
| title_sort |
capn10 gene is associated with insulin resistance phenotypes in the spanish population. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/8c43057a41e243b4b0be2318d447c863 |
| work_keys_str_mv |
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