Reversible modulation of circadian time with chronophotopharmacology

Reversible modulation of circadian time with chronophotopharmacology

The circadian clock is an internal mechanism that controls various physiological processes, such as the sleep-wake cycle, but its precise regulation is challenging. Here, the authors develop a visible light-responsive inhibitor of casein kinase I which controls the period and phase of cellular and t...

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Autores principales: Dušan Kolarski, Carla Miró-Vinyals, Akiko Sugiyama, Ashutosh Srivastava, Daisuke Ono, Yoshiko Nagai, Mui Iida, Kenichiro Itami, Florence Tama, Wiktor Szymanski, Tsuyoshi Hirota, Ben L. Feringa
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8c435936c7ba49a88eeb55cc1fca042c
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spelling oai:doaj.org-article:8c435936c7ba49a88eeb55cc1fca042c2021-12-02T15:00:39ZReversible modulation of circadian time with chronophotopharmacology10.1038/s41467-021-23301-x2041-1723https://doaj.org/article/8c435936c7ba49a88eeb55cc1fca042c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23301-xhttps://doaj.org/toc/2041-1723The circadian clock is an internal mechanism that controls various physiological processes, such as the sleep-wake cycle, but its precise regulation is challenging. Here, the authors develop a visible light-responsive inhibitor of casein kinase I which controls the period and phase of cellular and tissue circadian rhythms in a reversible manner.Dušan KolarskiCarla Miró-VinyalsAkiko SugiyamaAshutosh SrivastavaDaisuke OnoYoshiko NagaiMui IidaKenichiro ItamiFlorence TamaWiktor SzymanskiTsuyoshi HirotaBen L. FeringaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dušan Kolarski
Carla Miró-Vinyals
Akiko Sugiyama
Ashutosh Srivastava
Daisuke Ono
Yoshiko Nagai
Mui Iida
Kenichiro Itami
Florence Tama
Wiktor Szymanski
Tsuyoshi Hirota
Ben L. Feringa
Reversible modulation of circadian time with chronophotopharmacology
description The circadian clock is an internal mechanism that controls various physiological processes, such as the sleep-wake cycle, but its precise regulation is challenging. Here, the authors develop a visible light-responsive inhibitor of casein kinase I which controls the period and phase of cellular and tissue circadian rhythms in a reversible manner.
format article
author Dušan Kolarski
Carla Miró-Vinyals
Akiko Sugiyama
Ashutosh Srivastava
Daisuke Ono
Yoshiko Nagai
Mui Iida
Kenichiro Itami
Florence Tama
Wiktor Szymanski
Tsuyoshi Hirota
Ben L. Feringa
author_facet Dušan Kolarski
Carla Miró-Vinyals
Akiko Sugiyama
Ashutosh Srivastava
Daisuke Ono
Yoshiko Nagai
Mui Iida
Kenichiro Itami
Florence Tama
Wiktor Szymanski
Tsuyoshi Hirota
Ben L. Feringa
author_sort Dušan Kolarski
title Reversible modulation of circadian time with chronophotopharmacology
title_short Reversible modulation of circadian time with chronophotopharmacology
title_full Reversible modulation of circadian time with chronophotopharmacology
title_fullStr Reversible modulation of circadian time with chronophotopharmacology
title_full_unstemmed Reversible modulation of circadian time with chronophotopharmacology
title_sort reversible modulation of circadian time with chronophotopharmacology
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8c435936c7ba49a88eeb55cc1fca042c
work_keys_str_mv AT dusankolarski reversiblemodulationofcircadiantimewithchronophotopharmacology
AT carlamirovinyals reversiblemodulationofcircadiantimewithchronophotopharmacology
AT akikosugiyama reversiblemodulationofcircadiantimewithchronophotopharmacology
AT ashutoshsrivastava reversiblemodulationofcircadiantimewithchronophotopharmacology
AT daisukeono reversiblemodulationofcircadiantimewithchronophotopharmacology
AT yoshikonagai reversiblemodulationofcircadiantimewithchronophotopharmacology
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AT tsuyoshihirota reversiblemodulationofcircadiantimewithchronophotopharmacology
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