Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.

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Autores principales:	Peter J. Watson, Christopher J. Millard, Andrew M. Riley, Naomi S. Robertson, Lyndsey C. Wright, Himali Y. Godage, Shaun M. Cowley, Andrew G. Jamieson, Barry V. L. Potter, John W. R. Schwabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c4612cc08aa4272b0bb9490a5928eeb
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spelling	oai:doaj.org-article:8c4612cc08aa4272b0bb9490a5928eeb2021-12-02T17:32:06ZInsights into the activation mechanism of class I HDAC complexes by inositol phosphates10.1038/ncomms112622041-1723https://doaj.org/article/8c4612cc08aa4272b0bb9490a5928eeb2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11262https://doaj.org/toc/2041-1723Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.Peter J. WatsonChristopher J. MillardAndrew M. RileyNaomi S. RobertsonLyndsey C. WrightHimali Y. GodageShaun M. CowleyAndrew G. JamiesonBarry V. L. PotterJohn W. R. SchwabeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter J. Watson Christopher J. Millard Andrew M. Riley Naomi S. Robertson Lyndsey C. Wright Himali Y. Godage Shaun M. Cowley Andrew G. Jamieson Barry V. L. Potter John W. R. Schwabe Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
description	Class I histone deacetylase complexes can be activated by inositol phosphates. Here, the authors investigate the stereochemical requirements for activation; use the crystal structure to understand substrate recognition, and suggest an entropically driven mechanism of allostery.
format	article
author	Peter J. Watson Christopher J. Millard Andrew M. Riley Naomi S. Robertson Lyndsey C. Wright Himali Y. Godage Shaun M. Cowley Andrew G. Jamieson Barry V. L. Potter John W. R. Schwabe
author_facet	Peter J. Watson Christopher J. Millard Andrew M. Riley Naomi S. Robertson Lyndsey C. Wright Himali Y. Godage Shaun M. Cowley Andrew G. Jamieson Barry V. L. Potter John W. R. Schwabe
author_sort	Peter J. Watson
title	Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
title_short	Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
title_full	Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
title_fullStr	Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
title_full_unstemmed	Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
title_sort	insights into the activation mechanism of class i hdac complexes by inositol phosphates
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8c4612cc08aa4272b0bb9490a5928eeb
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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

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