Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Nerve growth factor (NGF) contributes to the sustained growth and metastasis of pancreatic cancer cells. Here, the authors develop a gold nanocluster-coupled siRNA against NGF that efficiently silences theNGFgene and inhibits tumour growth of pancreatic cancer in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yifeng Lei, Lixue Tang, Yangzhouyun Xie, Yunlei Xianyu, Lingmin Zhang, Peng Wang, Yoh Hamada, Kai Jiang, Wenfu Zheng, Xingyu Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c4855616b44477eaaf1566e42217856
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c4855616b44477eaaf1566e42217856
record_format	dspace
spelling	oai:doaj.org-article:8c4855616b44477eaaf1566e422178562021-12-02T14:40:37ZGold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer10.1038/ncomms151302041-1723https://doaj.org/article/8c4855616b44477eaaf1566e422178562017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15130https://doaj.org/toc/2041-1723Nerve growth factor (NGF) contributes to the sustained growth and metastasis of pancreatic cancer cells. Here, the authors develop a gold nanocluster-coupled siRNA against NGF that efficiently silences theNGFgene and inhibits tumour growth of pancreatic cancer in mice.Yifeng LeiLixue TangYangzhouyun XieYunlei XianyuLingmin ZhangPeng WangYoh HamadaKai JiangWenfu ZhengXingyu JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifeng Lei Lixue Tang Yangzhouyun Xie Yunlei Xianyu Lingmin Zhang Peng Wang Yoh Hamada Kai Jiang Wenfu Zheng Xingyu Jiang Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
description	Nerve growth factor (NGF) contributes to the sustained growth and metastasis of pancreatic cancer cells. Here, the authors develop a gold nanocluster-coupled siRNA against NGF that efficiently silences theNGFgene and inhibits tumour growth of pancreatic cancer in mice.
format	article
author	Yifeng Lei Lixue Tang Yangzhouyun Xie Yunlei Xianyu Lingmin Zhang Peng Wang Yoh Hamada Kai Jiang Wenfu Zheng Xingyu Jiang
author_facet	Yifeng Lei Lixue Tang Yangzhouyun Xie Yunlei Xianyu Lingmin Zhang Peng Wang Yoh Hamada Kai Jiang Wenfu Zheng Xingyu Jiang
author_sort	Yifeng Lei
title	Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
title_short	Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
title_full	Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
title_fullStr	Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
title_full_unstemmed	Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
title_sort	gold nanoclusters-assisted delivery of ngf sirna for effective treatment of pancreatic cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8c4855616b44477eaaf1566e42217856
work_keys_str_mv	AT yifenglei goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT lixuetang goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT yangzhouyunxie goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT yunleixianyu goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT lingminzhang goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT pengwang goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT yohhamada goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT kaijiang goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT wenfuzheng goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer AT xingyujiang goldnanoclustersassisteddeliveryofngfsirnaforeffectivetreatmentofpancreaticcancer
_version_	1718390251361140736

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Ejemplares similares