Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle

Abstract Ionizable cyclodextrins have attracted increasing attention in host–guest chemistry and pharmaceutical industry, mainly due to the introduction of favorable electrostatic interactions. The ionizable cyclodextrins could not only enhance its own solubility but also induce oppositely charged g...

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Autores principales:	He-Lue Sun, Ying-Ming Zhang, Yong Chen, Yu Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c4b25b6f06d49c7a341c3cad5423a47
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spelling	oai:doaj.org-article:8c4b25b6f06d49c7a341c3cad5423a472021-12-02T16:08:01ZPolyanionic Cyclodextrin Induced Supramolecular Nanoparticle10.1038/s41598-016-0026-z2045-2322https://doaj.org/article/8c4b25b6f06d49c7a341c3cad5423a472016-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-016-0026-zhttps://doaj.org/toc/2045-2322Abstract Ionizable cyclodextrins have attracted increasing attention in host–guest chemistry and pharmaceutical industry, mainly due to the introduction of favorable electrostatic interactions. The ionizable cyclodextrins could not only enhance its own solubility but also induce oppositely charged guests to form more stable complex. However, the aggregation induced by charged cyclodextrins has rarely been reported. In this work, guided by the concept of molecular-induced aggregation, a series of carboxyl modified cyclodextrins were synthesized via “click” and hydrolysis reaction. Then, UV-vis spectrum was used to investigate the aggregating behaviors induced by these cyclodextrins towards the cationic guest molecules. The results showed that only the hepta-carboxyl-β-cyclodextrin could induce the guest molecules to self-assemble into supramolecular spherical nanoparticles. Meanwhile, it could form stable inclusion complex with amantadine, a drug for anti-Parkinson and antiviral. The assembly behaviors were investigated by dynamic light scattering, scanning electron microscope, atomic force microscope, transmission electron microscope and NMR spectroscopy. The supramolecular nanoparticles induced by hepta-carboxyl-β-CD and its inclusion with amantadine could be used to encapsulate the model drug and achieve its controlled releasing behaviors.He-Lue SunYing-Ming ZhangYong ChenYu LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 6, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q He-Lue Sun Ying-Ming Zhang Yong Chen Yu Liu Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
description	Abstract Ionizable cyclodextrins have attracted increasing attention in host–guest chemistry and pharmaceutical industry, mainly due to the introduction of favorable electrostatic interactions. The ionizable cyclodextrins could not only enhance its own solubility but also induce oppositely charged guests to form more stable complex. However, the aggregation induced by charged cyclodextrins has rarely been reported. In this work, guided by the concept of molecular-induced aggregation, a series of carboxyl modified cyclodextrins were synthesized via “click” and hydrolysis reaction. Then, UV-vis spectrum was used to investigate the aggregating behaviors induced by these cyclodextrins towards the cationic guest molecules. The results showed that only the hepta-carboxyl-β-cyclodextrin could induce the guest molecules to self-assemble into supramolecular spherical nanoparticles. Meanwhile, it could form stable inclusion complex with amantadine, a drug for anti-Parkinson and antiviral. The assembly behaviors were investigated by dynamic light scattering, scanning electron microscope, atomic force microscope, transmission electron microscope and NMR spectroscopy. The supramolecular nanoparticles induced by hepta-carboxyl-β-CD and its inclusion with amantadine could be used to encapsulate the model drug and achieve its controlled releasing behaviors.
format	article
author	He-Lue Sun Ying-Ming Zhang Yong Chen Yu Liu
author_facet	He-Lue Sun Ying-Ming Zhang Yong Chen Yu Liu
author_sort	He-Lue Sun
title	Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
title_short	Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
title_full	Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
title_fullStr	Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
title_full_unstemmed	Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
title_sort	polyanionic cyclodextrin induced supramolecular nanoparticle
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8c4b25b6f06d49c7a341c3cad5423a47
work_keys_str_mv	AT heluesun polyanioniccyclodextrininducedsupramolecularnanoparticle AT yingmingzhang polyanioniccyclodextrininducedsupramolecularnanoparticle AT yongchen polyanioniccyclodextrininducedsupramolecularnanoparticle AT yuliu polyanioniccyclodextrininducedsupramolecularnanoparticle
_version_	1718384670461132800

Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle

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