Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study

Vishal Vennu, Saad M BindawasDepartment of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The purpose of this study was to examine the relationship between self-reported falls, doctor-diagnosed knee osteoarthritis (OA), and health-r...

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Autores principales:	Vennu V, Bindawas SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	ages 45-79 doctor-diagnosed cross-sectional study self-reported. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8c4b4e71fcb44df8a919d6b149c637f7
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spelling	oai:doaj.org-article:8c4b4e71fcb44df8a919d6b149c637f72021-12-02T07:44:46ZRelationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study1178-1998https://doaj.org/article/8c4b4e71fcb44df8a919d6b149c637f72014-05-01T00:00:00Zhttps://www.dovepress.com/relationship-between-falls-knee-osteoarthritis-and-health-related-qual-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Vishal Vennu, Saad M BindawasDepartment of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The purpose of this study was to examine the relationship between self-reported falls, doctor-diagnosed knee osteoarthritis (OA), and health-related quality of life (HRQoL). We hypothesized that falls and knee OA would be associated with poor HRQoL on both disease-specific and generic measures.Methods: This cross-sectional study used data from the publicly available Osteoarthritis Initiative data sets. A total of 4,484 subjects aged 45–79 years at baseline were divided into three subpopulations: those who had neither a history of falling nor doctor-diagnosed knee OA; those who had either a self-reported history of falling or doctor-diagnosed knee OA; and those who had both a self-reported history of falling and doctor-diagnosed knee OA. HRQoL was assessed using both disease-specific and generic measures. Multiple regression analyses were used to examine the relationship between self-reported falls, doctor-diagnosed knee OA, and HRQoL assessed using the Knee Injury and Osteoarthritis Outcome Score-Quality of Life (KOOS-QoL) subscale and two Short Form-12 (SF-12) summary scales. The models were adjusted for participant sociodemographic, lifestyle, and clinical characteristics.Results: Falls and knee OA were significantly associated with lower scores on the KOOS-QoL (β= −34.4, standard error 2.27, P≤0.0001) and on the physical component scale of the SF-12 (β= −9.44, standard error 0.90, P<0.0001). No significant relationship was found with the mental component scale score when adjusted for sociodemographic, lifestyle, and clinical characteristics.Conclusion: When compared with those having neither a self-reported history of falling nor doctor-diagnosed knee OA and those with a self-reported history of falling or doctor-diagnosed knee OA, persons with both conditions (falls and knee OA) had significantly lower KOOS-QoL and physical component scale scores after adjusting for sociodemographic, lifestyle, and clinical characteristics. Future research should assess potential mediating factors in an effort to improve HRQoL in persons with knee OA who are at high risk of falling.Keywords: osteoarthritis, quality of life, fallsVennu VBindawas SMDove Medical Pressarticleages 45-79doctor-diagnosedcross-sectional studyself-reported.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 793-800 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	ages 45-79 doctor-diagnosed cross-sectional study self-reported. Geriatrics RC952-954.6
spellingShingle	ages 45-79 doctor-diagnosed cross-sectional study self-reported. Geriatrics RC952-954.6 Vennu V Bindawas SM Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
description	Vishal Vennu, Saad M BindawasDepartment of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi ArabiaBackground: The purpose of this study was to examine the relationship between self-reported falls, doctor-diagnosed knee osteoarthritis (OA), and health-related quality of life (HRQoL). We hypothesized that falls and knee OA would be associated with poor HRQoL on both disease-specific and generic measures.Methods: This cross-sectional study used data from the publicly available Osteoarthritis Initiative data sets. A total of 4,484 subjects aged 45–79 years at baseline were divided into three subpopulations: those who had neither a history of falling nor doctor-diagnosed knee OA; those who had either a self-reported history of falling or doctor-diagnosed knee OA; and those who had both a self-reported history of falling and doctor-diagnosed knee OA. HRQoL was assessed using both disease-specific and generic measures. Multiple regression analyses were used to examine the relationship between self-reported falls, doctor-diagnosed knee OA, and HRQoL assessed using the Knee Injury and Osteoarthritis Outcome Score-Quality of Life (KOOS-QoL) subscale and two Short Form-12 (SF-12) summary scales. The models were adjusted for participant sociodemographic, lifestyle, and clinical characteristics.Results: Falls and knee OA were significantly associated with lower scores on the KOOS-QoL (β= −34.4, standard error 2.27, P≤0.0001) and on the physical component scale of the SF-12 (β= −9.44, standard error 0.90, P<0.0001). No significant relationship was found with the mental component scale score when adjusted for sociodemographic, lifestyle, and clinical characteristics.Conclusion: When compared with those having neither a self-reported history of falling nor doctor-diagnosed knee OA and those with a self-reported history of falling or doctor-diagnosed knee OA, persons with both conditions (falls and knee OA) had significantly lower KOOS-QoL and physical component scale scores after adjusting for sociodemographic, lifestyle, and clinical characteristics. Future research should assess potential mediating factors in an effort to improve HRQoL in persons with knee OA who are at high risk of falling.Keywords: osteoarthritis, quality of life, falls
format	article
author	Vennu V Bindawas SM
author_facet	Vennu V Bindawas SM
author_sort	Vennu V
title	Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
title_short	Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
title_full	Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
title_fullStr	Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
title_full_unstemmed	Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study
title_sort	relationship between falls, knee osteoarthritis, and health-related quality of life: data from the osteoarthritis initiative study
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8c4b4e71fcb44df8a919d6b149c637f7
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Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study

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