Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions

Background: Auditory hallucinations (AH) are typically associated with schizophrenia (SZ), but they are also prevalent in bipolar disorder (BD). Despite the large body of research on the neural correlates of AH in SZ, the pathophysiology underlying AH remains unclear. Few studies have examined the n...

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Autores principales:	Melissa Hwang, Youkyung S. Roh, Jessica Talero, Bruce M. Cohen, Justin T. Baker, Roscoe O. Brady, Dost Öngür, Ann K. Shinn
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Auditory hallucinations Schizophrenia Bipolar disorder Resting state functional magnetic resonance imaging Functional connectivity Cerebellum Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8c4ddf8bb402439c9a4922ec0b1caedb
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spelling	oai:doaj.org-article:8c4ddf8bb402439c9a4922ec0b1caedb2021-11-28T04:31:20ZAuditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions2213-158210.1016/j.nicl.2021.102893https://doaj.org/article/8c4ddf8bb402439c9a4922ec0b1caedb2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003375https://doaj.org/toc/2213-1582Background: Auditory hallucinations (AH) are typically associated with schizophrenia (SZ), but they are also prevalent in bipolar disorder (BD). Despite the large body of research on the neural correlates of AH in SZ, the pathophysiology underlying AH remains unclear. Few studies have examined the neural substrates associated with propensity for AH in BD. Investigating AH across the psychosis spectrum has the potential to inform about the neural signature associated with the trait of AH, irrespective of psychiatric diagnosis. Methods: We compared resting state functional magnetic resonance imaging data in psychosis patients with (n = 90 AH; 68 SZ, 22 BD) and without (n = 55 NAH; 16 SZ, 39 BD) lifetime AH. We performed region of interest (ROI)-to-ROI functional connectivity (FC) analysis using 91 cortical, 15 subcortical, and 26 cerebellar atlas-defined regions. The primary aim was to identify FC differences between patients with and without lifetime AH. We secondarily examined differences between AH and NAH within each diagnosis. Results: Compared to the NAH group, patients with AH showed higher FC between cerebellum and frontal (left precentral gyrus), temporal [right middle temporal gyrus (MTG), left inferior temporal gyrus (ITG), left temporal fusiform gyrus)], parietal (bilateral superior parietal lobules), and subcortical (left accumbens, left palldium) brain areas. AH also showed lower FC between temporal lobe regions (between right ITG and right MTG and bilateral superior temporal gyri) relative to NAH. Conclusions: Our findings suggest that dysconnectivity involving the cerebellum and temporal lobe regions may be common neurofunctional elements associated with AH propensity across the psychosis spectrum. We also found dysconnectivity patterns that were unique to lifetime AH within SZ or bipolar psychosis, suggesting both common and distinct mechanisms underlying AH pathophysiology in these disorders.Melissa HwangYoukyung S. RohJessica TaleroBruce M. CohenJustin T. BakerRoscoe O. BradyDost ÖngürAnn K. ShinnElsevierarticleAuditory hallucinationsSchizophreniaBipolar disorderResting state functional magnetic resonance imagingFunctional connectivityCerebellumComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102893- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Auditory hallucinations Schizophrenia Bipolar disorder Resting state functional magnetic resonance imaging Functional connectivity Cerebellum Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Auditory hallucinations Schizophrenia Bipolar disorder Resting state functional magnetic resonance imaging Functional connectivity Cerebellum Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Melissa Hwang Youkyung S. Roh Jessica Talero Bruce M. Cohen Justin T. Baker Roscoe O. Brady Dost Öngür Ann K. Shinn Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
description	Background: Auditory hallucinations (AH) are typically associated with schizophrenia (SZ), but they are also prevalent in bipolar disorder (BD). Despite the large body of research on the neural correlates of AH in SZ, the pathophysiology underlying AH remains unclear. Few studies have examined the neural substrates associated with propensity for AH in BD. Investigating AH across the psychosis spectrum has the potential to inform about the neural signature associated with the trait of AH, irrespective of psychiatric diagnosis. Methods: We compared resting state functional magnetic resonance imaging data in psychosis patients with (n = 90 AH; 68 SZ, 22 BD) and without (n = 55 NAH; 16 SZ, 39 BD) lifetime AH. We performed region of interest (ROI)-to-ROI functional connectivity (FC) analysis using 91 cortical, 15 subcortical, and 26 cerebellar atlas-defined regions. The primary aim was to identify FC differences between patients with and without lifetime AH. We secondarily examined differences between AH and NAH within each diagnosis. Results: Compared to the NAH group, patients with AH showed higher FC between cerebellum and frontal (left precentral gyrus), temporal [right middle temporal gyrus (MTG), left inferior temporal gyrus (ITG), left temporal fusiform gyrus)], parietal (bilateral superior parietal lobules), and subcortical (left accumbens, left palldium) brain areas. AH also showed lower FC between temporal lobe regions (between right ITG and right MTG and bilateral superior temporal gyri) relative to NAH. Conclusions: Our findings suggest that dysconnectivity involving the cerebellum and temporal lobe regions may be common neurofunctional elements associated with AH propensity across the psychosis spectrum. We also found dysconnectivity patterns that were unique to lifetime AH within SZ or bipolar psychosis, suggesting both common and distinct mechanisms underlying AH pathophysiology in these disorders.
format	article
author	Melissa Hwang Youkyung S. Roh Jessica Talero Bruce M. Cohen Justin T. Baker Roscoe O. Brady Dost Öngür Ann K. Shinn
author_facet	Melissa Hwang Youkyung S. Roh Jessica Talero Bruce M. Cohen Justin T. Baker Roscoe O. Brady Dost Öngür Ann K. Shinn
author_sort	Melissa Hwang
title	Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
title_short	Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
title_full	Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
title_fullStr	Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
title_full_unstemmed	Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions
title_sort	auditory hallucinations across the psychosis spectrum: evidence of dysconnectivity involving cerebellar and temporal lobe regions
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8c4ddf8bb402439c9a4922ec0b1caedb
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Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions

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