DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.
<h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregion...
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2014
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oai:doaj.org-article:8c508f0d8e494bdca4110695a9b7a55c2021-11-25T06:08:36ZDNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.1932-620310.1371/journal.pone.0102112https://doaj.org/article/8c508f0d8e494bdca4110695a9b7a55c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25019640/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregionally-advanced HNC to induction chemotherapy by evaluating the expression pattern of DNA repair proteins.<h4>Methods</h4>Expression of a panel of DNA-repair proteins in formalin-fixed paraffin embedded specimens from a cohort of 37 HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation were analyzed using quantitative immunohistochemistry.<h4>Results</h4>We found that XPF (an ERCC1 binding partner) and phospho-MAPKAP Kinase 2 (pMK2) are novel biomarkers for HNSCC patients undergoing platinum-based induction chemotherapy. Low XPF expression in HNSCC patients is associated with better response to induction chemoradiotherapy, while high XPF expression correlates with a worse response (p = 0.02). Furthermore, low pMK2 expression was found to correlate significantly with overall survival after induction plus chemoradiation therapy (p = 0.01), suggesting that pMK2 may relate to chemoradiation therapy.<h4>Conclusions</h4>We identified XPF and pMK2 as novel DNA-repair biomarkers for locoregionally-advanced HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation. Our study provides insights for the use of DNA repair biomarkers in personalized diagnostics strategies. Further validation in a larger cohort is indicated.Tanguy Y SeiwertXiaoZhe WangJana HeitmannVivian Villegas-BergazziKam SprottStephen FinnEsther O'ReganAllan D FarrowRalph R WeichselbaumMark W LingenEzra E W CohenKerstin StensonDavid T WeaverEverett E VokesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102112 (2014) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| description |
<h4>Background</h4>Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of patients with locoregionally-advanced HNC to induction chemotherapy by evaluating the expression pattern of DNA repair proteins.<h4>Methods</h4>Expression of a panel of DNA-repair proteins in formalin-fixed paraffin embedded specimens from a cohort of 37 HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation were analyzed using quantitative immunohistochemistry.<h4>Results</h4>We found that XPF (an ERCC1 binding partner) and phospho-MAPKAP Kinase 2 (pMK2) are novel biomarkers for HNSCC patients undergoing platinum-based induction chemotherapy. Low XPF expression in HNSCC patients is associated with better response to induction chemoradiotherapy, while high XPF expression correlates with a worse response (p = 0.02). Furthermore, low pMK2 expression was found to correlate significantly with overall survival after induction plus chemoradiation therapy (p = 0.01), suggesting that pMK2 may relate to chemoradiation therapy.<h4>Conclusions</h4>We identified XPF and pMK2 as novel DNA-repair biomarkers for locoregionally-advanced HNC patients undergoing platinum-based induction chemotherapy prior to definitive chemoradiation. Our study provides insights for the use of DNA repair biomarkers in personalized diagnostics strategies. Further validation in a larger cohort is indicated. |
| format |
article |
| author |
Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes |
| author_facet |
Tanguy Y Seiwert XiaoZhe Wang Jana Heitmann Vivian Villegas-Bergazzi Kam Sprott Stephen Finn Esther O'Regan Allan D Farrow Ralph R Weichselbaum Mark W Lingen Ezra E W Cohen Kerstin Stenson David T Weaver Everett E Vokes |
| author_sort |
Tanguy Y Seiwert |
| title |
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_short |
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_full |
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_fullStr |
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_full_unstemmed |
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| title_sort |
dna repair biomarkers xpf and phospho-mapkap kinase 2 correlate with clinical outcome in advanced head and neck cancer. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/8c508f0d8e494bdca4110695a9b7a55c |
| work_keys_str_mv |
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